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Eosinophilic esophagitis: Demographic, clinical, endoscopic, histological and allergological characteristics in children and teenagers in a region of central Spain

Elisa Gómez Torrijos1, Pilar Sánchez Miranda2, Paloma Donado Palencia2, Araceli Castro Jimenez1, Joaquin Rodriguez Sánchez3, Yesica Mendez Díaz1, Lucia Moreno Lozano1, Rosa García Rodríguez1

1Allergy Department. Hospital General Universitario de Ciudad Real. Calle Obispo Rafael Torija s/n 13005. Ciudad Real, Spain
2Pediatric Department. Hospital General Universitario de Ciudad Real. Calle Obispo Rafael Torija s/n 13005. Ciudad Real, Spain
3Digestive Department. Hospital General Universitario de Ciudad Real. Calle Obispo Rafael Torija s/n 13005. Ciudad Real, Spain

J Investig Allergol Clin Immunol 2016; Vol. 27(2)
doi: 10.18176/jiaci.0112

Background: Eosinophilic esophagitis (EoE) is a chronic inflammatory emerging disease of the oesophagus with immunoallergic aetiology. Until now, few studies about this disease in children and adolescents have been published
Objectives: To study the demographic, clinical, serologic, endoscopic-histological and allergologic characteristics of the patients and their atopic and digestive comorbidities.
Methodology: It is an prospective observacional study in children and adolescents (<16 years) assessed in a multidisciplinary specialized eosinpophilic esopahgitis unit in a tertiary referral centre in the central region of Spain carried out between 2011-2015.
Results: Thirty-five patients were included in the study. Twenty-eight (80%) were male. The mean age was 9.6 years, 83% were atopic and 28% reported a family history of atopy. The most common symptom were dysphagia (51%).Eosinophilia was detected in blood in 60% of patients. Eosinophil cationic protein and total IgE were elevated in 88% and 77% of patients, respectively. The most frequent endoscopic finding were linear grooves (57%). Skin tests with aeroallergens were positive in 82% of patients (pollen 62% and food 60% ). The atopic comorbidities detected were asthma (48%) and rhinoconjunctivitis (37%). Digestive diseases were more often associated with gastritis and Helicobacter pylori infection (17%).
Conclusions: Our results are similar to those reported previously. EoE is more common in boys, with history of atopy, sensitized to airborne allergens and food. These results support that the EoE can be considered an atopic disease and the role of the allergist in the early diagnosis and treatment of this disease.

Key words: Children, Teenagers, Eosinophilic esophagitis, Atopic comorbidities, Digestives comorbiditie, Allergens, Esophagoscopy.