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Case Report |
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Hypereosinophilia, Hyper-IgE Syndrome,
and Atopic Dermatitis in a Toddler With Food
Hypersensitivity |
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E Estrada-Reyes,1 MP
Hernández-Román,1 JD Gamboa-Marrufo,2
A Valencia-Herrera,3 AA Nava-Ocampo4,5 |
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1Hospital Angeles Metropolitano,
México DF, Mexico
2Departament of Internal Medicine, Hospital Infantil de
México Federico Gómez, México DF, Mexico
3Service of Dermatology Hospital Infantil de México
Federico Gómez, México DF, Mexico
4Divison of Clinical Pharmacology & Toxicology, Hospital
for Sick Children, Toronto, Canada
5PharmaReasons, Toronto, Canada |
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J Investig Allergol Clin Immunol
2008; Vol. 18(2): 131-135 |
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Abstract |
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We describe a 20-month-old
girl with
hypereosinophilia,
hyper-immunoglobulin
(Ig) E syndrome, and
atopic dermatitis.
Her peripheral
eosinophil count and
IgE plasma levels
were 2.65 109/L and
6702 IU/mL,
respectively.
Specifi c IgE levels
for a variety of
foods and inhalants
were high and
single-blind food
challenges were
positive for cow’s
milk, hen’s egg, oat,
wheat, and soy. When
the patient received
an extensively
hydrolyzed milk
formula, an
exclusion diet, and
2 mg/kg of
prednisone daily,
the atopic
dermatitis partially
improved.
Further improvement
was observed with 1
mg/kg of
azathioprine daily.
Long-term clinical
response was
satisfactory. We
suggest that food
hypersensitivity
should be ruled out
in patients with
hypereosinophilia,
hyper-IgE syndrome,
and atopic
dermatitis.
Azathioprine may be
a good therapeutic
alternative for
treatment in such
cases.
Key words:
Atopic dermatitis.
Food allergy.
Hypereosinophilia.
Hyper-IgE syndrome.
Immunological
diagnosis. |
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