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Original Article |
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Interrelationship Between Skin
Sensitization, Rhinitis, and Asthma in Patients With
Allergic Rhinitis: A Study of Spain and Portugal |
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A Valero,1,2 C Pereira,3
C Loureiro,4 C Martínez-Cócera,5 C
Murio,6 P Rico,7 R Palomino,8
I Dávila9 |
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1 Allergy Unit, Pneumology and
Respiratory Allergy Department, ICT Hospital Clinic,
Universitat de Barcelona, Spain (Spanish Study
Coordinator)
2 Centro de Investigación Biomédica en Red de
Enfermedades Respiratorias (CIBERES), Spain
3 Immunoallergology Department, Coimbra University
Hospital, Coimbra, Portugal, (President of Iberian
Chapter of the Sociedad Latinoamericana de Alergia, Asma
e Inmunología [SLAAI]).
4 Immunoallergology Department, Coimbra University
Hospital, Coimbra, Portugal (Portuguese Study
Coordinator)
5 Allergy Department, Hospital Clínico Universitario de
Madrid, Spain (Vice-President of SLAAI)
6 Almirall Prodesfarma, Barcelona, Spain
7 Medical Department, ALK-Abelló, S.A Madrid, Spain
8 Gestió Organització Comunicació S.A (GOC), Barcelona,
Spain
9 Allergy Department, Hospital Clínico Universitario de
Salamanca, Spain (Iberian Chapter of SLAAI) |
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J Investig Allergol Clin Immunol
2009; Vol. 19(3): 167-172 |
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Abstract |
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Objective:
Allergic rhinitis
can determine the
presence and type of
asthma. The main aim
of this study was to
evaluate the link
between
allergic rhinitis,
asthma, and skin
test sensitization
in patients with
allergic rhinitis.
Methods:
Patients with
allergic rhinitis,
aged 10 to 50 years,
were consecutively
enrolled at
different allergy
centers in Spain and
Portugal.
All the patients
underwent skin prick
tests with a panel
of 20 biologically
standardized
aeroallergens.
Allergic rhinitis
was classified
according to
etiology and the
Allergic Rhinitis
and its Impact on
Asthma guidelines
and asthma was
classified according
to the Global
Initiative for
Asthma guidelines.
Results: A
total of 3225
patients, with a
mean age of 27
years, were
evaluated. House
dust mites and grass
and olive tree
pollens were the
most common
aeroallergens. The
mean (SD) number of
positive skin tests
per patient was 6.5
(4), the mean wheal
size was 42.3 (28)
mm2, and the mean
atopy index was 6.5
(2). Forty-nine
percent of the
patients had
concomitant asthma.
Asthma severity was
associated with a
longer time since
onset (P<.04) and
allergic rhinitis
severity (P<.001).
Patients with
concomitant asthma
had a significantly
higher number of
aeroallergens and
sensitization
intensity than those
without asthma
(P<.001).
Conclusions:
In this broad
population sample,
the presence and
type of asthma was
influenced by skin
sensitization and
both time since
onset and severity
of allergic
rhinitis.
Key words:
Aeroallergen
sensitization.
Rhinitis and asthma
comorbidity. Skin
prick test.
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