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Original Article |
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Vitamin D Receptor Gene BSMI, FOKI,
APAI, and TAQI Polymorphisms and the Risk of Atopic
Dermatitis |
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Kılıç S1, Sılan F2,
Hız MM3, Işık S1, Ögretmen Z1,
Özdemir Ö2 |
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1Canakkale Onsekiz Mart
University, Faculty of Medicine, Department of
Dermatology, Çanakkale, Turkey
2Canakkale Onsekiz Mart University, Faculty
of Medicine, Department of Medical Genetics, Çanakkale,
Turkey
3Canakkale Onsekiz Mart University, Faculty
of Science & Arts, Department of Biology, Subdivision of
Molecular Biology, Çanakkale, Turkey |
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J Investig Allergol Clin Immunol
2016; Vol. 26(2): 106-110
doi: 10.18176/jiaci.0020 |
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Abstract |
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Background and
Objective: The
association between
vitamin D receptor (VDR)
gene polymorphisms
and the risk of skin
diseases has been
widely studied, yet
there is only one
study on atopic
dermatitis. In this
study, we aimed to
investigate the
association between
4 VDR
polymorphisms and
atopic dermatitis.
Patients and
Methods: This
cross-sectional case
control study was
performed between
March 2013 and April
2014 at the
University Hospital
in Çanakkale,
Turkey. Peripheral
blood samples were
collected in EDTA
tubes. DNA
extraction was
performed using the
spin column
procedure. The
VDR
polymorphisms FokI
(rs2228570), BsmI
(rs1544410), ApaI
(rs7975232), and
TaqI (rs731236) were
determined by
polymerase chain
reaction-restriction
fragment length
polymorphism
analysis in 42
atopic dermatitis
patients and 96
healthy individuals
from a Turkish
population.
Results: The
VDR rs1544410
polymorphism
increased the risk
of atopic dermatitis
in our Turkish
population [OR,
12.2; 95%CI,
0.44-336; P=.05].
The FoqI, TaqI, and
ApaI polymorphisms
were not
significantly
associated with
atopic dermatitis
susceptibility.
Conclusion:
The VDR Fok1,
TaqI, and ApaI gene
polymorphisms were
not associated with
the risk of atopic
dermatitis in the
Turkish population
but the BsmI
polymorphism was
found to increase
risk.
Key words:
FokI. rs2228570.
BsmI. rs1544410.
ApaI. rs7975232.
TaqI. rs731236. |
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