The Journal of Investigational Allergology and Clinical Immunology (J Investig Allergol Clin Immunol) provides an attractive and very active forum for basic and clinical research in allergology and clinical immunology. The journal publishes original works, reviews, short communications and opinions. It is the Official Journal ofthe Spanish Society of Allergology and Clinical Immunology (SEAIC). The journal will appear bimonthly (6 issues each year). The peer-review system, based on a team of internationally renowned and committed editors, guarantees the scientific quality of the papers.

Current ISSUE

2021; volume 31, Issue 4
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Efficacy and Safety of Up-dosing Antihistamines in Chronic Spontaneous Urticaria: A Systematic Review of the Literature
Iriarte Sotés P, Armisén M, Usero-Bárcena T, Rodriguez Fernández A, Otero Rivas MM, Gonzalez MT, Meijide Calderón A, Veleiro B, Urtigal, the Galician Group of Interest in Urticaria
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Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Quinolones
Doña I, Blanca-López N, Boteanu C, Cueva-Oliver B, Fernández-Sánchez FJ, Gajate P, García-Avilés MC, García-Núñez I, Lobera T, Moreno E, Rojas P, Rosado A
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Original Articles

PAGE Study: Summary of a Study Protocol to Estimate the Prevalence of Severe Asthma in Spain Using Big Data Methods
Almonacid Sánchez C, Melero Moreno C, Quirce Gancedo S, Sánchez-Herrero MG, Álvarez Gutiérrez FJ, Bañas Conejero D, Cardona V, Soriano JB
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Low Expression of ICAM-1 in Blood Eosinophils in Patients With Active Eosinophilic Esophagitis
Perez-Lucendo I, Gomez Torrijos E, Donado P, Melero R, Feo-Brito F, Urra JM
[summary] [PDF full-Text] [Supplemental Materials]

Severe Cutaneous Adverse Reactions to Drugs in Latin America: The RACGRAD Study
Rojas Mejía DV, Zwiener RD, Cardona Villa R, Ramírez LF, Silva Espinosa DL, Zanacchi VA, Piraino Sosa P, Ensina LF, Giavina Bianchi P, Coelho Portilho N, Vivolo Aún M, Matos Benavides E, Martínez Ruíz DM, Jares E, Serrano Reyes CD
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Practitioner’s Corner

Anaphylaxis After Cutaneous Application of Argan Oil
de las Marinas Alvarez MD, Martorell Calatayud C, Castillo Fernandez M, Alvariño Martín M, Félix Toledo R, Pineda de la Losa F, Cerdá Mir JC, Martorell Aragonés A
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Anaphylaxis Induced by Beer
Navarro L, Lazo L, Pineda P, Labrador-Horrillo M, Roger A, Basagaña M
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Anaphylactic Shock to a DEET-Containing Insect Repellent
Giangrande N, García-Menaya J, Vergara-Prieto E, Pineda de la Losa F, Castillo-Fernández M, Cordobés-Durán C, Marcos- Fernández M, Bobadilla-González P
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Kounis Syndrome due to Urapidil
Herrera-Lasso V, Dordal MT, Alonso G, Camprubí I, Lleonart R
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Cumulative Pollen Concentration Curves for Pollen Allergy Diagnosis
Hoffmann TM, Travaglini A, Brighetti MA, Acar Şahin A, Arasi S, Bregu B, Caeiro E, Caglayan Sozmen S, Charpin D, Delgado L, Dimou M, Fiorilli M, Fonseca JA, Goksel O, Kalpaklioglu F, Lame B, Mazon A, Mesonjesi E, Nieto A, Öztürk A, Pajno G, Papadopoulos NG, Pellegrini E, Pereira AM, Pinar NM, Pinter E, Priftanji A, Sackesen C, Sfika I, Suarez J, Thibaudon M, Tripodi S, Ugus U, Villella V, Matricardi PM, Dramburg S, @IT.2020 study team, Pereira M
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Epithelial Permeability to Ole e 1 Is More Dependent on the Functional State of the Bronchial Epithelium Than on the Activity of Der p 1 Protease Acting as an Adjuvant to the Bystander Allergen
López-Rodríguez JC, González M, Bogas G, Mayorga C, Villalba M, Batanero E
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Efficacy of Benralizumab and Clinical Course of IgG4 in Eosinophilic Granulomatosis With Polyangiitis
Miyata Y, Inoue H, Homma T, Tanaka A, Sagara H
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Profilins and Food-Dependent Exercise-Induced Anaphylaxis
Gómez Torrijos E, Gratacós Gómez AR, González Jimenez OM, Joyanes Romo JB, Palacios Cañas A, García Rodríguez R
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Two Cases of Anaphylaxis to Tranexamic Acid Confirmed by Drug Provocation Testsing: What About Skin Test?
El Hanache H, Verdaguer M, Collin L, Babin M, Favrelière S, Vidal Husser S, Maissiat MH, Hoppe A, Morisset M
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Unsustained Response to Benralizumab in Eosinophilic Asthma After 3 Years of Therapy With Mepolizumab
Kurosawa M, Shimizu Y, Sutoh Y, Sutoh E
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Psychiatric and Clinical Characteristics of Hereditary Angioedema Patients Who Experienced Attacks During COVID-19
Mete Gökmen N, Kuman Tunçel O, Boğatekin G, Bulut G, Demir S, Gelincik A, Tunakan Dalgıç C, Mungan D
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Delayed Reaction to Gadobutrol in a Nurse With Myocarditis After SARS-Cov-2 Infection
Gallardo A, Gracia Bara MT, Moreno EM, Laffond E, Muñoz Bellido FJ, Martin C, Sobrino M, Dávila I
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Letters to the Editor

Eosinophil Count Could Be More Sensitive in Induced Sputum Than in Peripheral Blood for Phenotyping of Patients With Severe Eosinophilic Asthma
Caballero ML, Dominguez-Ortega J, Nin-Valencia AR, Sánchez-Ocando H, Barranco P
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Prevalence and Influence of COVID-19 in Asthma Control and Lung Function in Severe Asthma Patients Receiving Biological Treatment
Díaz-Campos RM, García-Moguel I, Pina-Maiquez I, Fernández-Rodríguez C, Melero-Moreno C
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