Ahead of Print

Review

Position Paper on the Treatment of Eosinophilic Esophagitis With Dupilumab
Tomás-Pérez M, Domenech-Witek J, Ávila-Castellano MR, Carballas-Vázquez C, Vásquez-Bautista AA, Jover-Cerdá V, González-Mendiola R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1038
[summary] [PDF full-Text]

Climate Change-Associated Environmental Factors and Pollutants: Impact on Allergic Diseases, Epidemiology, Severity, and Health Care Burden
Montoro J, Antolín-Amérigo D, Izquierdo-Domínguez A, Zapata JJ, García-Gallardo MV, González R, Armentia A, Rondón C, Fernández MM, Pedrero SG, Valero A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1067
[summary] [PDF full-Text] [Supplemental Materials]

Prostaglandin E2: A Potential Link Between NSAIDs and the Menstrual Cycle, Cofactors of Food-Dependent Anaphylaxis
Tubita V, Mir Ihara P, González-Matamala MF, Picado C, Muñoz Cano RM
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1070
[summary] [PDF full-Text]

Original Articles

Deep intronic 9q21.11 polymorphism contributes to atopic dermatitis risk through methylation regulated expression of tight junction protein 2
Eliza Lim YY, Yie Sio Y, Say YH, Reginald K, Tim Chew F
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0978
[summary] [PDF full-Text] [Supplemental Materials]

Investigating Novel Food Sensitization: A Real-Life Prevalence Study of Cricket, Locust, and Mealworm IgE-Reactivity in Naïve allergic Individuals
Scala E, Abeni D, Villella V, ViIlalta D, Cecchi L, Caprini E, Asero R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0986
[summary] [PDF full-Text] [Supplemental Materials]

Mast Cell Activation Profile and TFH13 Detection Discriminate Food Anaphylaxis Versus Sensitization
Ollé L, García-García L, Ruano M, Bartra J, González-Navarro EA, Pérez M, Roca-Ferrer J, Pascal M, Martín M, Muñoz-Cano R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0995
[summary] [PDF full-Text] [Supplemental Materials]

Pharmacokinetics and Safety of Bilastine 10 mg/d in Children Aged 2 to 5 Years With Allergic Rhinoconjunctivitis or Urticaria: A Phase 3 Clinical Trial
Majorek-Olechowska B, Slomskis T, Zollerová L, Martín I, Sánchez C, Gilaberte I, Arranz P, on behalf of the BILA-4021/PED Research Group
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1003
[summary] [PDF full-Text] [Supplemental Materials]

Fecal IgE Analyses Reveal a Role for Stratifying Peanut-Allergic Patients
Czolk R, Codreanu-Morel F, de Nies L, Busi SB, Halder R, Hunewald O, Boehm TM, Hefeng FQ, De Beaufort C, Wilmes P, Ollert M, Kuehn A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1008
[summary] [PDF full-Text] [Supplemental Materials]

Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals
Swiontek K, Fischer J, Hedin F, Revets D, Riel S, Chakrapani N, Mackenstedt U, Biedermann T, Kuehn A, Cosma A, Ollert M, Hilger C
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1028
[summary] [PDF full-Text] [Supplemental Materials]

Study of Urinary Protein Biomarkers in Hereditary Angioedema
Wu J, Tang X, Zhou N, Wang X, Liu P, Zhang Z, Zhang S, Zhi Y
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1032
[summary] [PDF full-Text] [Supplemental Materials]

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users
Sousa-Pinto B, Savouré M, Vieira RJ, Amaral R, Czarlewski W, Bedbrook A, Valiulis A, Kvedariene V, Brussino L, Gemicioglu B, Haahtela T, Klimek L, Kraxner H, Larenas-Linnemann DE, Pfaar O, Regateiro FS, Samolinski B, Taborda-Barata L, Toppila-Salmi S, Ventura MT, Ansotegui IJ, Braido F, Canonica GW, Cecchi L, Cruz AA, Devillier P, Fokkens WJ, Gil-Mata S, Giuliano AFM, Ivancevich JC, Kuna P, Kupczyk M, Louis G, Louis R, Makris M, Morais-Almeida M, Mullol J, Nadif R, Niedoszytko M, Okamoto Y, Ollert M, Papadopoulos NG, Patella V, Pawankar R, Pereira AM, Pétré B, Pham-Thi N, Roche N, Rouadi PW, Sastre J, Scichilone N, Sheikh A, Sova M, Todo-Bom A, Yorgancioglu A, Zidarn M, Anto JM, Zuberbier T, Fonseca JA, Bousquet J
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1047
[summary] [PDF full-Text] [Supplemental Materials]

Causal Effect Between Gut Microbiota, Gut Bacterial Pathway, and Chronic Spontaneous Urticaria: A Large-Scale Bidirectional Mendelian Randomization Analysis
Yao Y, Chen J, Cao H, Lu Z, Shen H, Ji J, Jiao Q
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1054
[summary] [PDF full-Text] [Supplemental Materials]

Validation of an Environmental Exposure Chamber for Assessment of Allergy to Grass Pollen
García-Gutiérrez I, Solórzano-Zepeda C, Sánchez-García V, Ramírez-Mateo E, Antolín-Amérigo D, Zheng Y, Rioja Carrera A, León Hernando I, Hernando Pérez ME, De la Hoz Caballer B
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1036
[summary] [PDF full-Text] [Supplemental Materials]

Dissecting the Sensitization Profiles to Parvalbumins From 12 Freshwater Fish Species to Improve Diagnosis of Fish Allergy
Kalic Kamath T, Djukic T, Kamath SD, Lengger N, Ottersbach S, Uranowska-Kostrubala K, Mladenovic Stokanic M, Park KH, Forstenlechner P, Aumayr M, Lamorte G, Velickovic Cirkovic T, Hemmer W, Breiteneder H, Hafner C
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1069
[summary] [PDF full-Text] [Supplemental Materials]

Immunological Parameters for Assessing the In Vitro Safety and Efficacy of Allergoid Mixtures for Immunotherapy
Calzada D, Parody N, Beitia JM, Dominguez-Ortega J, Gonzalez-de-Olano D, Renshaw-Calderón A, Osuna C, Moya R, Carnés J
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1061
[summary] [PDF full-Text] [Supplemental Materials]

Adrenaline: A Lifeline for Rapid Drug Desensitization in Hypersensitive Patients
Gil-Serrano J, Galvan-Blasco P, Pereira-Gonzalez J, Salvany-Pijuan A, Gonzalez Di-Paolo M, Guilarte M, Luengo O, Sala-Cunill A, Cardona V, Labrador-Horrillo M
J Investig Allergol Clin Immunol 2026; Vol. 36(2)
doi: 10.18176/jiaci.1075
[summary] [PDF full-Text] [Supplemental Materials]

Biomarkers of Tolerance to Baked Milk in Cow’s Milk-Allergic Children at High Risk of Anaphylaxis
Domínguez O, Riggioni C, Poyatos E, Jiménez-Feijoo RM, Piquer M, Machinena A, Folqué M, Ortiz de Landazuri I, Torradeflot M, Lozano J, Alsina L, Pascal M, Alvaro-Lozano M
J Investig Allergol Clin Immunol 2026; Vol. 36(1)
doi: 10.18176/jiaci.1074
[summary] [PDF full-Text] [Supplemental Materials]

Regular Allergen Exposure During Oral Immunotherapy Alters the Transcriptomic Innate Immune Response After Cellular Restimulation in Children With Egg Allergy
Hinkkanen VI, Savinko T, Palosuo K, Alenius H, Mäkelä MJ, Karisola P
J Investig Allergol Clin Immunol 2026; Vol. 36(2)
doi: 10.18176/jiaci.1079
[summary] [PDF full-Text] [Supplemental Materials]

Component-Resolved IgE and IgG4 Profiling Reveals Robust IgG4 Responses Primarily to Abundant Hymenoptera Allergens During Venom Immunotherapy and in Beekeepers
Blank S, Dorn B, Seiringer P, Grosch J, Slusarenko BO, Dittmar M, Kaczmarcyk R, Rogner D, Jung A, Plail L, Eberlein B, Biedermann T, Darsow U, Brockow K, Schmidt-Weber CB, Jakob T
J Investig Allergol Clin Immunol 2026; Vol. 36(1)
doi: 10.18176/jiaci.1072
[summary] [PDF full-Text] [Supplemental Materials]

Practitioner's Corner

Letters to the Editor

Component-Based Assessment of the Main Allergens in Honeybee Venom in a Spanish Allergic Population
Carballada González F, Abel-Fernández E, González Guzmán LA, Pineda de la Losa F
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1050
[summary] [PDF full-Text] [Supplemental Materials]

Ongoing Concerns With Honeybee Venom Immunotherapy
Khan S
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1060
[summary] [PDF full-Text]

Cytokine Release Reaction After Subcutaneous Daratumumab: Possible Relationship With Hymenoptera Allergy
Torres Górriz MC, Borrás Cuartero J, Valls Ten T, Beltrán Agost S, Enrique E
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1078
[summary] [PDF full-Text]