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Review

Position Paper on the Treatment of Eosinophilic Esophagitis With Dupilumab
Tomás-Pérez M, Domenech-Witek J, Ávila-Castellano MR, Carballas-Vázquez C, Vásquez-Bautista AA, Jover-Cerdá V, González-Mendiola R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1038
[summary] [PDF full-Text]

Climate Change-Associated Environmental Factors and Pollutants: Impact on Allergic Diseases, Epidemiology, Severity, and Health Care Burden
Montoro J, Antolín-Amérigo D, Izquierdo-Domínguez A, Zapata JJ, García-Gallardo MV, González R, Armentia A, Rondón C, Fernández MM, Pedrero SG, Valero A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1067
[summary] [PDF full-Text] [Supplemental Materials]

Original Articles

Deep intronic 9q21.11 polymorphism contributes to atopic dermatitis risk through methylation regulated expression of tight junction protein 2
Eliza Lim YY, Yie Sio Y, Say YH, Reginald K, Tim Chew F
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0978
[summary] [PDF full-Text] [Supplemental Materials]

Investigating Novel Food Sensitization: A Real-Life Prevalence Study of Cricket, Locust, and Mealworm IgE-Reactivity in Naïve allergic Individuals
Scala E, Abeni D, Villella V, ViIlalta D, Cecchi L, Caprini E, Asero R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0986
[summary] [PDF full-Text] [Supplemental Materials]

Mast Cell Activation Profile and TFH13 Detection Discriminate Food Anaphylaxis Versus Sensitization
Ollé L, García-García L, Ruano M, Bartra J, González-Navarro EA, Pérez M, Roca-Ferrer J, Pascal M, Martín M, Muñoz-Cano R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0995
[summary] [PDF full-Text] [Supplemental Materials]

Pharmacokinetics and Safety of Bilastine 10 mg/d in Children Aged 2 to 5 Years With Allergic Rhinoconjunctivitis or Urticaria: A Phase 3 Clinical Trial
Majorek-Olechowska B, Slomskis T, Zollerová L, Martín I, Sánchez C, Gilaberte I, Arranz P, on behalf of the BILA-4021/PED Research Group
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1003
[summary] [PDF full-Text] [Supplemental Materials]

Fecal IgE Analyses Reveal a Role for Stratifying Peanut-Allergic Patients
Czolk R, Codreanu-Morel F, de Nies L, Busi SB, Halder R, Hunewald O, Boehm TM, Hefeng FQ, De Beaufort C, Wilmes P, Ollert M, Kuehn A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1008
[summary] [PDF full-Text] [Supplemental Materials]

Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals
Swiontek K, Fischer J, Hedin F, Revets D, Riel S, Chakrapani N, Mackenstedt U, Biedermann T, Kuehn A, Cosma A, Ollert M, Hilger C
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1028
[summary] [PDF full-Text] [Supplemental Materials]

Study of Urinary Protein Biomarkers in Hereditary Angioedema
Wu J, Tang X, Zhou N, Wang X, Liu P, Zhang Z, Zhang S, Zhi Y
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1032
[summary] [PDF full-Text] [Supplemental Materials]

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users
Sousa-Pinto B, Savouré M, Vieira RJ, Amaral R, Czarlewski W, Bedbrook A, Valiulis A, Kvedariene V, Brussino L, Gemicioglu B, Haahtela T, Klimek L, Kraxner H, Larenas-Linnemann DE, Pfaar O, Regateiro FS, Samolinski B, Taborda-Barata L, Toppila-Salmi S, Ventura MT, Ansotegui IJ, Braido F, Canonica GW, Cecchi L, Cruz AA, Devillier P, Fokkens WJ, Gil-Mata S, Giuliano AFM, Ivancevich JC, Kuna P, Kupczyk M, Louis G, Louis R, Makris M, Morais-Almeida M, Mullol J, Nadif R, Niedoszytko M, Okamoto Y, Ollert M, Papadopoulos NG, Patella V, Pawankar R, Pereira AM, Pétré B, Pham-Thi N, Roche N, Rouadi PW, Sastre J, Scichilone N, Sheikh A, Sova M, Todo-Bom A, Yorgancioglu A, Zidarn M, Anto JM, Zuberbier T, Fonseca JA, Bousquet J
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1047
[summary] [PDF full-Text] [Supplemental Materials]

Causal Effect Between Gut Microbiota, Gut Bacterial Pathway, and Chronic Spontaneous Urticaria: A Large-Scale Bidirectional Mendelian Randomization Analysis
Yao Y, Chen J, Cao H, Lu Z, Shen H, Ji J, Jiao Q
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1054
[summary] [PDF full-Text] [Supplemental Materials]

Validation of an Environmental Exposure Chamber for Assessment of Allergy to Grass Pollen
García-Gutiérrez I, Solórzano-Zepeda C, Sánchez-García V, Ramírez-Mateo E, Antolín-Amérigo D, Zheng Y, Rioja Carrera A, León Hernando I, Hernando Pérez ME, De la Hoz Caballer B
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1036
[summary] [PDF full-Text] [Supplemental Materials]

Dissecting the Sensitization Profiles to Parvalbumins From 12 Freshwater Fish Species to Improve Diagnosis of Fish Allergy
Kalic Kamath T, Djukic T, Kamath SD, Lengger N, Ottersbach S, Uranowska-Kostrubala K, Mladenovic Stokanic M, Park KH, Forstenlechner P, Aumayr M, Lamorte G, Velickovic Cirkovic T, Hemmer W, Breiteneder H, Hafner C
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1069
[summary] [PDF full-Text] [Supplemental Materials]

Immunological Parameters for Assessing the In Vitro Safety and Efficacy of Allergoid Mixtures for Immunotherapy
Calzada D, Parody N, Beitia JM, Dominguez-Ortega J, Gonzalez-de-Olano D, Renshaw-Calderón A, Osuna C, Moya R, Carnés J
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1061
[summary] [PDF full-Text] [Supplemental Materials]

Practitioner's Corner

Short Communications

Bioinformatics-Based Prediction of B- and T-Cell Epitopes in R-Mandelonitrile Lyase, a Recently Described Peach Allergen
López-Matas MA, Martín-López L, Vílchez-Sánchez F, Pedrosa M, Rodríguez-Pérez R, Domínguez-Ortega J, Carnés J
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1052
[summary] [PDF full-Text] [Supplemental Materials]

Safety and Efficacy of the First Venom Immunotherapy for Allergy to Vespa velutina nigrithorax: Interim Analysis of the W-STING Study
Carballada F, Parra A, Liñares T, Giangrande N, Varela S, Meijide Á, Castro M, Tabar AI
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1058
[summary] [PDF full-Text] [Supplemental Materials]

Predictive Factors and Optimization of Omalizumab in Chronic Spontaneous Urticaria: A Multicenter Study of 257 Patients
Ceravalls J, Giménez-Arnau AM, Expósito-Serrano V, Fernández Chico N, Lara Moya A, Bielsa I, Ribó P, Mascaró- Hereza B, Bonfill-Ortí M, Spertino J, Serra E, Baliu-Piqué C, Melé-Ninot G
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1053
[summary] [PDF full-Text] [Supplemental Materials]

Generalized Eczema as a Transient Paradoxical Adverse Effect of Dupilumab
Betancor D, Valverde-Monge M, Díaz-Recuero JL, Jo-Velasco ME, Del Pozo V, Sastre J
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1051
[summary] [PDF full-Text] [Supplemental Materials]

Use of a 24-Hour Hotline vs Voicemail for Off-Hour Support During Oral Immunotherapy for Food Allergy
Paradis V, Des Roches A, Elbany C, Braun C, Graham FJ, Samaan K, Labrosse R, Paradis L, Bégin P
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1063
[summary] [PDF full-Text] [Supplemental Materials]

Revisited the Impact of Misdiagnosed Drug Hypersensitivity in Hospitalized Patients: A 10-Year Perspective
Bernaola J, Otal-Buesa M, Barroso B, Valverde-Monge M, Sastre J
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1056
[summary] [PDF full-Text]

Sensitization to Pru p 7 in Peach-Allergic Patients Sensitized to Pru p 3 in Areas of High Exposure to Cypress Pollen
Tomás-Pérez M, Vera-Berrios RN, Casas-Saucedo R, Galleani C, González-Bravo L, Gonzalo-Fernández A, González-Pérez A, Rodríguez-Mazariego E, Ruano-Zaragoza M, Zambrano-Ibarra G, Bartra-Tomás J
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1065
[summary] [PDF full-Text] [Supplemental Materials]

Obese Asthma Syndrome: Multiple Inflammatory Patterns and A Key Solution
Bantulà M, García A, Picado C, Arismendi E
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1071
[summary] [PDF full-Text] [Supplemental Materials]

Reduced Prostaglandin D2 Production by Airway Fibroblasts in Nonsteroidal Anti-inflammatory Drug- Exacerbated Airway Disease
Roca-Ferrer J, Machado-Carvalho L, Picado C
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1062
[summary] [PDF full-Text] [Supplemental Materials]

Prioritization of Children With Anaphylaxis in Pediatric Emergency Departments: Results of a National Survey From Spain
Arroabarren Aleman E, de Vicente Jimenez TM, Alvarez García O, Baynova K, Candón Morillo R, Reche Frutos M
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1064
[summary] [PDF full-Text] [Supplemental Materials]

Lymphocyte-Stimulation Test for Diagnosis of Wheat- Induced Enterocolitis Syndrome in Children
Kajita N, Kusakawa G, Hirao K, Yokoyama S, Morikawa E, Morita K, Narita M, Yoshida K
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1085
[summary] [PDF full-Text] [Supplemental Materials]

Case Reports

Measurement of Fecal Calprotectin and Zonulin as Biomarkers in Adults With Fish-Induced Food Protein-Induced Enterocolitis Syndrome
Entrala A, Lluch-Bernal MM, Domínguez-Ortega J, Molero-Luis M, Crespo Sánchez G, Quirce S, Rodríguez-Pérez R
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1049
[summary] [PDF full-Text] [Supplemental Materials]

Hidden Dangers of Oral Contrast Media: Delayed Hypersensitivity to Sodium Amidotrizoate and Meglumine Amidotrizoate (Gastrografin)
Pardo-Manrique V, Amat-Samaranch V, Pascal M, Loli-Ausejo D, Sánchez-Fernández MC, Ruano-Zaragoza M
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1055
[summary] [PDF full-Text] [Supplemental Materials]

Anaphylaxis Induced by Milk Thistle (Silybum marianum) Seed Ingestion: A Case Report
Planas-Vinos M, Sala-Cunill A, Luengo O, Castillo Fernandez M, Galvan-Blasco P, Cardona V, Guilarte M, Labrador-Horrillo M, Gil-Serrano J
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1057
[summary] [PDF full-Text]

Successful Desensitization to Ramucirumab in Signet-Cell Gastric Adenocarcinoma
Villarreal-González RV, Madrazo-Morales M, Sáenz-Cantú KS, García Rosas C, Burguete-Torres A, Vidal-Gutiérrez O
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1066
[summary] [PDF full-Text]

A Case of Strongyloidiasis Mimicking a Drug Hypersensitivity Reaction to Imatinib
El Rhermoul FZ, Slater S, Madrigal-Burgaleta R
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1068
[summary] [PDF full-Text]

Catalase, a New Potential Allergen in Hypersensitivity to Avocado
Gómez-Fariñas C, Sánchez-Sánchez S, Pineda de La Losa F, López Rico MR, Parra Arrondo A, García-Paz V
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1073
[summary] [PDF full-Text]

Letters to the Editor

Component-Based Assessment of the Main Allergens in Honeybee Venom in a Spanish Allergic Population
Carballada González F, Abel-Fernández E, González Guzmán LA, Pineda de la Losa F
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1050
[summary] [PDF full-Text] [Supplemental Materials]

Ongoing Concerns With Honeybee Venom Immunotherapy
Khan S
J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.1060
[summary] [PDF full-Text]

Cytokine Release Reaction After Subcutaneous Daratumumab: Possible Relationship With Hymenoptera Allergy
Torres Górriz MC, Borrás Cuartero J, Valls Ten T, Beltrán Agost S, Enrique E
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1078
[summary] [PDF full-Text]