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Review

Climate Change-Associated Environmental Factors and Pollutants: Impact on Allergic Diseases, Epidemiology, Severity, and Health Care Burden
Montoro J, Antolín-Amérigo D, Izquierdo-Domínguez A, Zapata JJ, García-Gallardo MV, González R, Armentia A, Rondón C, Fernández MM, Pedrero SG, Valero A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1067
[summary] [PDF full-Text] [Supplemental Materials]

Perspectives in the Molecular Mechanisms Underlying Anaphylaxis
Esteban V, Skrabski F, Perales-Chorda C, Puente-Crespo Y, Muñoz-Cano R, Cardona V, Anaphylaxis Committee of the Spanish Society of Allergy and Immunology (SEAIC)
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1080
[summary] [PDF full-Text]

Original Articles

Pharmacokinetics and Safety of Bilastine 10 mg/d in Children Aged 2 to 5 Years With Allergic Rhinoconjunctivitis or Urticaria: A Phase 3 Clinical Trial
Majorek-Olechowska B, Slomskis T, Zollerová L, Martín I, Sánchez C, Gilaberte I, Arranz P, on behalf of the BILA-4021/PED Research Group
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1003
[summary] [PDF full-Text] [Supplemental Materials]

Fecal IgE Analyses Reveal a Role for Stratifying Peanut-Allergic Patients
Czolk R, Codreanu-Morel F, de Nies L, Busi SB, Halder R, Hunewald O, Boehm TM, Hefeng FQ, De Beaufort C, Wilmes P, Ollert M, Kuehn A
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1008
[summary] [PDF full-Text] [Supplemental Materials]

Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals
Swiontek K, Fischer J, Hedin F, Revets D, Riel S, Chakrapani N, Mackenstedt U, Biedermann T, Kuehn A, Cosma A, Ollert M, Hilger C
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1028
[summary] [PDF full-Text] [Supplemental Materials]

Study of Urinary Protein Biomarkers in Hereditary Angioedema
Wu J, Tang X, Zhou N, Wang X, Liu P, Zhang Z, Zhang S, Zhi Y
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1032
[summary] [PDF full-Text] [Supplemental Materials]

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users
Sousa-Pinto B, Savouré M, Vieira RJ, Amaral R, Czarlewski W, Bedbrook A, Valiulis A, Kvedariene V, Brussino L, Gemicioglu B, Haahtela T, Klimek L, Kraxner H, Larenas-Linnemann DE, Pfaar O, Regateiro FS, Samolinski B, Taborda-Barata L, Toppila-Salmi S, Ventura MT, Ansotegui IJ, Braido F, Canonica GW, Cecchi L, Cruz AA, Devillier P, Fokkens WJ, Gil-Mata S, Giuliano AFM, Ivancevich JC, Kuna P, Kupczyk M, Louis G, Louis R, Makris M, Morais-Almeida M, Mullol J, Nadif R, Niedoszytko M, Okamoto Y, Ollert M, Papadopoulos NG, Patella V, Pawankar R, Pereira AM, Pétré B, Pham-Thi N, Roche N, Rouadi PW, Sastre J, Scichilone N, Sheikh A, Sova M, Todo-Bom A, Yorgancioglu A, Zidarn M, Anto JM, Zuberbier T, Fonseca JA, Bousquet J
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1047
[summary] [PDF full-Text] [Supplemental Materials]

Causal Effect Between Gut Microbiota, Gut Bacterial Pathway, and Chronic Spontaneous Urticaria: A Large-Scale Bidirectional Mendelian Randomization Analysis
Yao Y, Chen J, Cao H, Lu Z, Shen H, Ji J, Jiao Q
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1054
[summary] [PDF full-Text] [Supplemental Materials]

Validation of an Environmental Exposure Chamber for Assessment of Allergy to Grass Pollen
García-Gutiérrez I, Solórzano-Zepeda C, Sánchez-García V, Ramírez-Mateo E, Antolín-Amérigo D, Zheng Y, Rioja Carrera A, León Hernando I, Hernando Pérez ME, De la Hoz Caballer B
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1036
[summary] [PDF full-Text] [Supplemental Materials]

Dissecting the Sensitization Profiles to Parvalbumins From 12 Freshwater Fish Species to Improve Diagnosis of Fish Allergy
Kalic Kamath T, Djukic T, Kamath SD, Lengger N, Ottersbach S, Uranowska-Kostrubala K, Mladenovic Stokanic M, Park KH, Forstenlechner P, Aumayr M, Lamorte G, Velickovic Cirkovic T, Hemmer W, Breiteneder H, Hafner C
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1069
[summary] [PDF full-Text] [Supplemental Materials]

Immunological Parameters for Assessing the In Vitro Safety and Efficacy of Allergoid Mixtures for Immunotherapy
Calzada D, Parody N, Beitia JM, Dominguez-Ortega J, Gonzalez-de-Olano D, Renshaw-Calderón A, Osuna C, Moya R, Carnés J
J Investig Allergol Clin Immunol 2025; Vol. 35(6)
doi: 10.18176/jiaci.1061
[summary] [PDF full-Text] [Supplemental Materials]

Adrenaline: A Lifeline for Rapid Drug Desensitization in Hypersensitive Patients
Gil-Serrano J, Galvan-Blasco P, Pereira-Gonzalez J, Salvany-Pijuan A, Gonzalez Di-Paolo M, Guilarte M, Luengo O, Sala-Cunill A, Cardona V, Labrador-Horrillo M
J Investig Allergol Clin Immunol 2026; Vol. 36(2)
doi: 10.18176/jiaci.1075
[summary] [PDF full-Text] [Supplemental Materials]

Biomarkers of Tolerance to Baked Milk in Cow’s Milk-Allergic Children at High Risk of Anaphylaxis
Domínguez O, Riggioni C, Poyatos E, Jiménez-Feijoo RM, Piquer M, Machinena A, Folqué M, Ortiz de Landazuri I, Torradeflot M, Lozano J, Alsina L, Pascal M, Alvaro-Lozano M
J Investig Allergol Clin Immunol 2026; Vol. 36(1)
doi: 10.18176/jiaci.1074
[summary] [PDF full-Text] [Supplemental Materials]

Regular Allergen Exposure During Oral Immunotherapy Alters the Transcriptomic Innate Immune Response After Cellular Restimulation in Children With Egg Allergy
Hinkkanen VI, Savinko T, Palosuo K, Alenius H, Mäkelä MJ, Karisola P
J Investig Allergol Clin Immunol 2026; Vol. 36(2)
doi: 10.18176/jiaci.1079
[summary] [PDF full-Text] [Supplemental Materials]

Component-Resolved IgE and IgG4 Profiling Reveals Robust IgG4 Responses Primarily to Abundant Hymenoptera Allergens During Venom Immunotherapy and in Beekeepers
Blank S, Dorn B, Seiringer P, Grosch J, Slusarenko BO, Dittmar M, Kaczmarcyk R, Rogner D, Jung A, Plail L, Eberlein B, Biedermann T, Darsow U, Brockow K, Schmidt-Weber CB, Jakob T
J Investig Allergol Clin Immunol 2026; Vol. 36(1)
doi: 10.18176/jiaci.1072
[summary] [PDF full-Text] [Supplemental Materials]

Practitioner's Corner

Letters to the Editor

Cytokine Release Reaction After Subcutaneous Daratumumab: Possible Relationship With Hymenoptera Allergy
Torres Górriz MC, Borrás Cuartero J, Valls Ten T, Beltrán Agost S, Enrique E
J Investig Allergol Clin Immunol 2025; Vol. 35(4)
doi: 10.18176/jiaci.1078
[summary] [PDF full-Text]

Reply to: "Differences in Molecular Sensitization Profiles Between a Spanish and Latin American Mite Allergic Patients"
Rial MJ, González-Pérez R, El-Qutob D, Alcover J
J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1092
[summary] [PDF full-Text]