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Two Immediate Hypersensitivity Reactions to Isatuximab Confirmed by the Complement Activation Test and Treated With Successful Rapid Desensitization

Cardenas Herrero A1*, Fernandez-Lozano C2*, Ramirez-Mateo E1, Alcalá-Rodriguez MG1, Solano-Solares E1, Blanchard-Rodriguez MJ3, Pueyo-Lopez C4, De La Hoz B1,5, Martínez-Botas J2,6** , Berges-Gimeno MP1,5**

1Allergology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
2Biochemistry Research Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
3Hematology Department, Hospital Ramón y Cajal, Madrid, IRYCIS, Madrid, Spain
4Pharmacy Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
5University of Alcalá (UAH), Alcalá de Henares, Spain
6Centro de Investigación Biomédica en Red Cáncer, Madrid, Spain
*Both authors contributed equally and should be considered first authors.
**Both authors should be considered corresponding authors.

J Investig Allergol Clin Immunol 2025; Vol. 35(5)
doi: 10.18176/jiaci.1089

Key words: Hypersensitivity, Isatuximab, Desensitization, Complement activation, Polysorbate 80