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An atypical case of idiopathic nonhistaminergic angioedema with anti-C1-INH antibodies

Bova M1*, Suffritti C2*, Kusumam J3, Caccia S4, Gelderman KA5, Berra S4, Loffredo S1-6, Santacroce R7, Petraroli A1, Roem-Haagsma D8, Margaglione M7, Spadaro G1, Kaplan AP9

1
Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Italy.
2Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.
3Dept. of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
4Department of Biomedical and Clinical Sciences “Luigi Sacco”, Università degli Studi di Milano, Milan, Italy.
5Sanquin Diagnotic Services, Amsterdam, The Netherlands.
6CNR Institute of Experimental Endocrinology and Oncology “G. Salvatore”, Naples, Italy.
7Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
8Sanquin Research, Amsterdam, The Netherlands.
9Dept. of Medicine, Division of Pulmonary, Critical Care, Allergy and Immunology, Medical University of South Carolina, Charleston, SC USA.
*Maria Bova and Chiara Suffritti are both first names. They contributed equally.

J Investig Allergol Clin Immunol 2022; Vol. 32(6)
doi: 10.18176/jiaci.0791

Key words: Angioedema, Acquired, C1-inhibitor, Anti-C1 inhibitor antibody, C1-inhibitor deficiency