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Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical manifestations, Diagnosis, Classification and Management

Yazdani R1, Habibi S1, Sharifi L2, Azizi G3, Abolhassani H1,4, Olbrich P5, Aghamohammadi A1

1Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran.
2Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran
3Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
4Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.
5Sección de Infectología e Inmunopatología, Unidad de Pediatría, Hospital Virgen del Rocío/Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain

J Investig Allergol Clin Immunol 2020; Vol. 30(1)
doi: 10.18176/jiaci.0388

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is the most frequent symptomatic antibody deficiency with a wide variety of infectious and non-infectious complications. Numerous studies demonstrated that different immunological and genetic defects are involved in the pathogenesis of CVID. However, in most cases, the genetic background of the disease remains unidentified. This review aims to discuss different aspects of CVID including epidemiology, pathogenesis, symptoms, diagnosis, classifications and management of the disease.

Key words: Common variable immunodeficiency, epidemiology, pathogenesis, symptoms, diagnosis, classifications, management