A patient suffered a myocardial injury as a manifestation of anaphylactic reaction to amoxicillinclavulanic acid administration. A cardiologic study (ergometry and catheterization) showed no obstructive coronary disease and prick test to amoxicillin was positive. Anaphylaxis may cause myocardial injury and the mechanism is likely to be vasospasm induced by mast cells and basophil mediators.

Key words: myocardial ischemia, anaphylaxis, adverse drug reaction, amoxicillin.