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Original Article |
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Chronic autoreactive urticaria at six
years of age |
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R. Asero, M. Lorini*, A. Tedeschi* |
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Allergy Unit, Clinica San Carlo,
Paderno Dugnano (Milano), and *First Division of
Internal Medicine, IRCCS
Ospedale Maggiore Policlinico, Milano, Italy |
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J Invest Allergol Clin Immunol
2004; Vol. 14(4): 343-345 |
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Abstract |
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A case of chronic
urticaria in a child
6 years old is
described. The
strong skin
reactivity upon
intradermal
injection of
autologous serum
suggested an
autoreactive
pathogenesis;
however, patient’s
serum was unable to
induce histamine
release from
basophils in-vitro,
indicating the
presence of a
histamine-releasing
factor specific
for mast cells, and
possibly other than
an anti-FcεRI or
anti-IgE antibody.
Intradermal test
with autologous
serum may be useful
in revealing the
autoreactive nature
of chronic urticaria
and can avoid a
frustrating search
for other causes of
the disease. In
children presenting
with chronic or
recurrent urticaria
the diagnostic
workup should
include the
autologous serum
skin test.
Key words:
autologous serum
skin test, childhood,
chronic urticaria. |
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