|
Return to Contents in this
Issue |
|
Case Report |
|
|
|
Diagnosis and Management of
Hypersensitivity Reactions Caused by Oxaliplatin |
|
|
|
T Herrero, 1 P Tornero,1
S Infante, 1 V Fuentes, 1 MN
Sánchez, 2 M De Barrio, 1 ML Baeza
1 |
|
1 Allergy and
2 Pharmacology Department, Hospital General
Universitario Gregorio Marañón, Madrid, Spain |
|
J Investig Allergol Clin Immunol
2006; Vol. 16(5): 327-330 |
|
|
|
Abstract |
|
Hypersensitivity
reactions to
oxaliplatin have
been increasing
since its
introduction at the
end of the 1990s,
but allergy tests
with antineoplastic
drugs are rarely
used to aid
diagnosis. We
describe 5 cases in
which
hypersensitivity
reactions to
oxaliplatin after
several courses of
chemotherapy were
managed by allergy
testing and
desensitization.
Skin prick tests
were negative at 1
mg/mL in all
patients, positive
at 10 mg/mL in 2
tested
patients, and
negative in 10
control subjects.
Intradermal tests
were positive and
not irritant at 0.01
to 0.001 mg/mL
concentrations. A
desensitization
protocol with
increasing
concentrations and
flow rates was
successfully
completed in all
patients. We
conclude that prick
and intradermal skin
tests are useful in
the diagnosis of
hypersensitivity
reactions to
oxaliplatin and that
the desensitization
protocol performed
avoided
discontinuation of
chemotherapy in all
patients.
Key words:
Desensitization.
Hypersensitivity
reactions.
Oxaliplatin.
Platinum analogs. |
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
