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Case Report |
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Repeated Massive Tongue Swelling Due
to the Combined Use of Estramustine Phosphate and
Angiotensin-Converting Enzyme Inhibitor |
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Y Kamata,1 M Iwamoto,1
T Kamimura,1
E Kanashiki,1 T Yoshio,1 H Okazaki,1 T Morita,2 S
Minota1 |
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1 Division of Rheumatology and
Clinical Immunology, Jichi Medical University, Tochigi,
Japan
2 Department of Urology, Jichi Medical University,
Tochigi, Japan |
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J Investig Allergol Clin Immunol
2006; Vol. 16(6): 388-390 |
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Abstract |
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A 70-year-old man
presenting with a
chief complaint of
tongue swelling had
been diagnosed with
prostate cancer 1
year earlier. He had
been on an oral
angiotensin-converting
enzyme inhibitor
(ACE) inhibitor for
hypertension for 20
years. Two months
before the fi rst of
4 episodes of tongue
swelling within a
period of 40 days,
he had been
prescribed oral
estramustine
phosphate (EMP) for
the prostate cancer.
He was admitted to
our hospital for the
evaluation after
massive swelling of
the tongue and
epiglottis which
necessitated
tracheotomy. Food
allergies, allergic
reactions to
environmental
factors, and
hereditary
angioneurotic edema
were excluded.
Massive swelling of
the tongue and
epiglottis
disappeared
completely after EMP
was discontinued. We
concluded that
angioedema was
induced by EMP used
concurrently with
the ACE inhibitor.
Key Words:
Estramustine
phosphate.
Angiotensin-converting
enzyme inhibitor.
Angioedema.
Tracheotomy.
Prostate cancer. |
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