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 Supplement |
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Comparative pharmacology of the H1
antihistamines |
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A del Cuvillo 1, J
Mullol 2, J Bartra 3, I Dávila
4, I Jáuregui 5, J Montoro 6,
J Sastre 7, AL Valero 3 |
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1 Clínica Dr. Lobatón, Cádiz, Spain;
2 Unitat de Rinologia, Servei d’Otorinolaringologia (ICEMEQ).
Hospital Clínic, Barcelona, Spain;
3 Unitat d’Al·lèrgia. Servei de Pneumologia i Al·lèrgia
Respiratòria. Hospital Clínic (ICT). Barcelona, Spain;
4 Servicio de Alergia. Hospital Clínico. Salamanca,
Spain;
5 Unidad de Alergia. Hospital de Basurto. Bilbao, Spain;
6 Unidad de Alergia. Hospital La Plana. Villarreal
(Castellón), Spain |
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J Investig Allergol Clin Immunol
2006; Vol. 16, Supplement 1:3-12 |
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Abstract |
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The United States
National Library of
Medicine defines the
term
pharmacokinetics as
“the dynamic and
kinetic mechanisms
of exogenous
chemical products,
and the absorption,
biotransformation,
distribution,
release, transport
and elimination of
drug substances
according to their
dosage and extent
and rate of
metabolism”.
Although the effi
cacy of the
different H1
antihistamines in
the treatment of
allergic patients is
similar, even when
comparing fi rst-
and second-generation
drugs, they are very
different in terms
of chemical
structure,
pharmacology and
toxic potential.
Consequently,
knowledge of their
pharmacokinetic and
pharmacodynamic
characteristics is
important for the
correct usage of
such drugs,
particularly in
patients belonging
to extreme age
groups, pregnant
women, or subjects
with concomitant
diseases.
.../...
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