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Case Report |
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Unilateral Conjunctival Chemosis as a
Unique Symptom of Nonsteroidal Anti-Inflammatory Drug
Intolerance |
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V Fuentes,1 C de
Frutos,2 M de Barrio,3 R Barranco,1
T Herrero,3 P Tornero3 |
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1 Private Practice, Madrid, Spain
2 Allergy Service, Hospital Universitario de la
Princesa, Madrid, Spain
3 Allergy Service, Hospital General Universitario
Gregorio Marañón, Madrid, Spain |
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J Investig Allergol Clin Immunol
2007; Vol. 17(1): 62-64 |
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Abstract |
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Patients with
nonsteroidal
anti-inflammatory
drug (NSAID)
intolerance usually
have cutanous-mucosal
or/and respiratory
symptoms.
We report the case
of a patient who
developed several
episodes of left-eye
conjunctivitis,
manifested as
conjunctival
chemosis, with no
other symptoms,
after taking
metamizole and other
unidentified NSAIDs.
We performed both a
single blind
placebo-controlled
oral
challenge test and
conjunctival
challenge test with
different NSAIDs.
The single blind
placebo-controlled
oral challenge was
positive to
ketoprofen and
diclofenac. The
conjunctival
challenge with
diclofenac and fl
urbiprofen was
negative. The
patient tolerated
celecoxib and
nabumetone.
We believe this to
be an exceptional
case of NSAID
intolerance as
conjunctival
chemosis has not
hitherto been
included in any of
the classic types of
pseudoallergic
reactions.
Key words:
NSAID intolerance.
Conjunctival
chemosis. |
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