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Modelling Diseases: The Allergens of
Olea europaea Pollen |
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J Quiralte,1 L
Palacios,1 R Rodríguez,2 B Cárdaba,2
JM Arias de Saavedra,1 M Villalba,3
JF Florido,3 C Lahoz2 |
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1 Allergology Section, Jaén Hospital
Complex, Jaén, Spain
2 Department of Biochemistry and Molecular Biology,
Faculty of Chemistry, Complutense University of Madrid,
Madrid, Spain and Immunology Service, Jiménez Díaz-CAPIO
Foundation, Madrid, Spain.
3 Allergology Unit, San Cecilio University Hospital,
Granada, Spain |
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J Investig Allergol Clin Immunol
2007; Vol. 17, Supplement 1: 76-82 |
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Abstract |
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This study analyzes
the infl uence of
the IgE response to
certain olive pollen
allergens in the
modulation of the
different clinical
phenotypes of
allergic disease and
their relationship
with the level of
exposure to pollen
and genetic factors.
Patients from high-exposure
areas had a complex
IgE antibody
response to
allergens of Olea
euroapea, which
included 3 or more
allergens in 75% of
cases. The majority
allergens were Ole e
1, Ole e 2 (profilin), Ole e 7 (lipid
transporting protein),
Ole e 9 (glucanase),
and Ole e 10.
The existence of the
antigen HLA-DR2(15)
led to a higher risk
of sensitization to
Ole e 10 and a
greater trend
towards the
development of
severe asthma, which
increased in the
presence of an anti-profi
lin IgE.
Thirty percent of
patients suffering
from pollinosis
simultaneously
presented allergy to
vegetable foods.
Anti-Ole e 7 IgE was
significantly
associated with
fruit anaphylaxis
and anti-profi lin
IgE was detected in
90% of patients with
oral syndrome.
Finally, we analyzed
the role of
glucanase and Ole e
10 as causes of the
pollen-latex-fruit
syndrome.
Key words:
Olive pollen
allergens. Bronchial
asthma. Food allergy.
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