|
Return to Contents in this
Issue |
|
Original Article |
|
|
|
Adverse Reactions of Prophylactic
Intravenous Immunoglobulin; A 13-Year Experience With
3004 Infusions in Iranian Patients With Primary
Immunodeficiency Diseases |
|
|
|
S Dashti-Khavidaki,1 A
Aghamohammadi,2,3 F Farshadi,1 M
Movahedi,2 N Parvaneh,2,3 N
Pouladi,3 K Moazzami,3 T Cheraghi,2
SA Mahdaviani,2 S Saghafi ,3 G
Heydari,3 S Abdollahzade,3 N
Rezaei4 |
|
1 Department of Clinical Pharmacy,
School of Pharmacy, Tehran University of Medical
Sciences, Tehran, Iran
2 Department of Allergy and Clinical Immunology,
Children’s Medical Center Hospital, Tehran University of
Medical Sciences, Tehran, Iran
3 Growth and Development Research Center, Children’s
Medical Center Hospital, Tehran University of Medical
Sciences, Tehran, Iran
4 Immunology, Asthma and Allergy Research Institute,
Tehran University of Medical Sciences, Tehran, Iran |
|
J Investig Allergol Clin Immunol
2009; Vol. 19(2): 139-145 |
|
|
|
Abstract |
|
Intravenous
immunoglobulin
(IVIG) replacement
therapy improves
health-related
quality of life in
patients with a
primary
immunodeficiency
disease, although
there have been
reports of adverse
reactions associated
with its regular
administration.
The study population
was composed of 99
patients with
primary antibody
defi ciencies. All
the patients were
diagnosed with a
primary
immunodeficiency
disease and received
at least 4 infusions
of IVIG at the
Children’s Medical
Center Hospital,
Tehran, Iran over a
13-year period
(1995-2007).
A total of 3004
infusions were
recorded, and 216
(7.2%) of these were
associated with
adverse reactions in
66 patients. Adverse
reactions were
classified as mild
(172 reactions),
moderate (41
reactions), and
severe (3
reactions). The rate
of adverse reaction
varied by diagnosis
from 3.35% in
patients with
X-linked
agammaglobulinemia
to 17.4% in IgG
subclass deficiency.
There were no
age-related
differences in the
rates of adverse
reactions.
Adverse reactions to
IVIG infusions are
occasionally
encountered;
therefore,
physicians and
nurses should be
aware of these
reactions in order
to manage and
prevent them.
Key words:
Adverse reactions.
Infusion.
Intravenous
immunoglobulin.
Primary antibody
defi ciencies.
Primary
immunodeficiency
diseases.
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
