|
Return to Contents in this
Issue |
|
Guidelines |
|
|
|
Guidelines on the Clinical Usefulness
of Determination of Specific Immunoglobulin E to Foods |
|
|
|
BE García,1 PM Gamboa,2
JA Asturias,3 M López-Hoyos,4 ML
Sanz,5 on behalf of the Clinical Immunology
Committee of the Spanish Society of Allergology and
Clinical Immunology (MT Caballero, JM García, M
Labrador, C Lahoz, N Longo Areso, J Martínez Quesada, L
Mayorga, FJ Monteseirín) |
|
1Hospital Virgen del Camino, Pamplona,
Spain
2Hospital Basurto, Bilbao, Spain
3Bial-Arístegui, Bilbao, Spain
4Hospital de Valdecilla, Santander, Spain
5Clínica Universidad de Navarra, Collaborative Center of
GA2LEN, Pamplona, Spain |
|
J Investig Allergol Clin Immunol
2009; Vol. 19(6): 423-432 |
|
|
|
Abstract |
|
The diagnostic gold
standard for food
allergy is challenge
with the culprit
food, particularly
in double-blind
placebo-controlled
challenge.
This approach
involves risks and
consumes both time
and resources. A
more efficient
system would be
desirable. The
detection of serum
specific
immunoglobulin E (sIgE)
against the culprit
food enables us to
establish
sensitization,
although this is not
always accompanied
by clinical
reactivity. Age,
symptoms
(immediate/late
reaction,
local/systemic
reaction),
concomitant
condition (eg,
atopic dermatitis,
pollinosis)
and selection sample
criteria (eg,
presence of symptoms
related to
ingestion, positive
skin prick test
result) can
influence the
detection and
concentration of IgE
against foods. We
analyze the clinical
usefulness of sIgE
determination in
light of studies in
which oral food
challenge is used as
the diagnostic
method. We review
clinical usefulness
at diagnosis and in
the decision to
reintroduce the
food, as well as the
prognostic value of
the determination of
IgE to foods.
Key words:
Specific IgE. Food
allergy. Diagnosis.
Prognosis.
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
