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Case Report |
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Urticaria Due to Antihistamines |
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L Sánchez Morillas,1 P
Rojas Pérez-Ezquerra,1 M Reaño Martos,1
ML Sanz,2 JJ Laguna Martínez1 |
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1Allergology Department, Hospital
Central de la Cruz Roja, Madrid, Spain
2Allergology Department, Clínica Universidad de Navarra,
Pamplona, Spain |
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J Investig Allergol Clin Immunol
2011; Vol. 21(1): 66-68 |
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Abstract |
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H1-antihistamines
are probably the
most frequently used
drugs in allergic
diseases, with
widely established
efficacy, tolerance,
and safety.
We report a patient
with urticaria due
to ingestion of
ebastine and
fexofenadine. Skin
prick tests, patch
tests, and basophil
activation tests
with the implicated
drugs and
antihistamines from
other families were
negative. The oral
challenges with the
implicated
antihistamines and
other antihistamines
tested were
positive, but the
patient tolerated an
oral challenge with
cetirizine. We
present a patient
with urticaria
induced by different
antihistamines in
whom the diagnosis
was established by
oral challenge. The
mechanism of
sensitization
remains unclear.
Key words:
Adverse drug
reaction.
Antihistamines.
Cross-reactivity.
Urticaria.
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