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Case Report


Topical dexketoprofen as a cause of photocontact dermatitis


R. López-Abad, Mª J. Paniagua, E. Botey, P. Gaig, P. Rodríguez, C. Richart.

Allergy Unit, Internal Medicine Department. Hospital Universitari de Tarragona Joan XXIII, Tarragona (Spain).

J Invest Allergol Clin Immunol 2004; Vol. 14(3): 247-249



We reported on the case of a patient who developed a cutaneous eruption in a photoexposed area 1 week after a continous topical treatment with dexketoprofen (Enangel®). Photopatch tests were positive for dexketoprofen, ketoprofen and piketoprofen and patch test was positive for piketoprofen. Control photopatch testing with dexketoprofen in 15 healthy volunteers was negative. Dexketoprofen, ketoprofen and piketoprofen are non-steroidal anti-inflamatory drugs (arylpropionic acid derivatives) often used as topical anti-inflammatory agents. It appears that the benzophenone moiety of their chemical structure is the cause of their photosensitivity and crossphotoreaction.

Key words: arylpropionic acid derivatives, cross-photoreaction, dexketoprofen, ketoprofen, non-steroidal antiinflammatory drugs, photoallergic contact dermatitis, piketoprofen.