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Original Article


Clinical features of patients showing Candida hypersensitivity: an observational study


R Asero1, G Bottazzi2

1Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (MI), Italy.
2Ambulatorio di Otorinolaringologia, Poliambulatorio Territoriale di Paderno Dugnano (MI), It

J Invest Allergol Clin Immunol 2004; Vol. 14(4): 309-311



Background: The significance of Candida albicans as an allergen is still unclear. This study aimed at investigating the clinical features of patients monosensitized to Candida.

Methods: Thirty-four adult patients monosensitized to the yeast Candida albicans selected from a population of >7000 subjects and referred for suspect respiratory allergy were studied. Ninety subjects monosensitized to different airborne allergens served as controls. Both patients and controls underwent a clinical examination at the ENT
department to detect possible nasal polyps.

Results: Male and female patients were equally distributed (17/17). The mean age of the patients was 58.4 years (range 23-75 years; median 59 years) vs 29.9 years (range 9-62 years) in controls (p <0.001). At baseline examination, 15 (44%) patients vs 5/90 (6%) controls were diagnosed as having nasal polyposis (p< 0.001). Polyposis was bilateral in 13/15 (87%) patients; 3 had “massive” polyps, and 4 had a clinical history of prior surgical intervention to remove nasal polyps. Eight patients (24%) had asthma, previously diagnosed as intrinsic in six cases. No patient had a history of aspirin-induced asthma (i.e. ASA triad). After one year 1/11 (9%) patients without polyps at the baseline examination had developed bilateral nasal polyposis.

Conclusion: Candida-hypersensitivity is uncommon, occurs in older ages, and is strongly associated with nasal polyposis.

Key words: Candida, Allergy, Chronic rhinitis, Nasal polyposis, Asthma.