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Original Article


The multiple faces of nonsteroidal antiinflammatory drug hypersensitivity


M. Sánchez-Borges1,2, A. Capriles-Hulett1,3, F. Caballero-Fonseca1,3

1 Centro Médico-Docente La Trinidad,
2 Clínica El Avila,
3 Centro Médico de Caracas, Caracas, Venezuela

J Invest Allergol Clin Immunol 2004; Vol. 14(4): 329-334



Based on the clinical picture and triggering drugs, allergic and pseudoallergic adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) can be classified in four patterns : respiratory, cutaneous, mixed and systemic. This categorization is useful for the purpose of describing patient populations included in studies about NSAID adverse reactions as well as for the routine management of the patient in the clinical setting.

Key words: Non steroidal anti-inflammatory drugs. Urticaria. Angioedema. Asthma. Cysteinil-leukotrienes. Cyclooxygenases.