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F-H Qian,1* Q Zhang,2*
L-F Zhou,3 G-F Jin,4 J-L Bai,5
K-S Yin3 |
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1Department of Respiratory Medicine,
Affi liated Hospital, Jiangsu University, Zhenjiang,
Jiangsu, China
2Department of Respiratory Medicine, Affi liated
Changzhou No.2 people s hospital, Nanjing Medical
University, Changzhou, China
3Department of Respiratory Medicine, First Affi liated
Hospital, Nanjing Medical University, Nanjing, China
4Department of Epidemiology and Biostatistics, Cancer
Research Center, Nanjing Medical University, Nanjing,
China
5Department of Epidemiology and Biostatistics, School of
Public Health, Nanjing Medical University, Nanjing,
China
*Both authors contributed equally to this article. |
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Abstract |
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Background and
objective: Cell
activation through
toll-like receptors
(TLRs) has robust
bipolar effects on
host immunity and
the pathogenesis of
asthma. The TLR2
subfamily is a
pivotal member of
the TLR family. We
sought to determine
whether mutations in
TLR2 subfamily genes
affect the risk of
asthma.
Methods: A
total of 318
asthmatic patients
and 352 nonasthmatic
controls were
recruited. Eight
single-nucleotide
polymorphisms in
TLR2 subfamily genes
were detected using
GenomeLab SNPstream
(Beckman Coulter,
Fullerton,
California, USA).
Results: We
found that patients
with the
TLR2/rs7656411 TT
variant homozygote
had a significantly
reduced risk of
asthma when compared
with those with the
GG wild-type
homozygote (adjusted
odds ratio [OR],
0.63; 95% confidence
interval [CI],
0.41-0.98; P=.036).
Furthermore, a
positive association
was observed between
the T allele of
rs2381289 in TLR6
and allergic
rhinitis in asthma
(OR, 1.79; 95% CI,
1.10-2.91; P=.025),
while the A allele
of rs11466651 in
TLR10 was negatively
associated with
allergic rhinitis
(OR, 0.49; 95% CI,
0.26-0.95; P=.046).
Conclusion:
Our results indicate
that a genetic
variant in the TLR2
subfamily may play a
role in
susceptibility to
asthma.
Key words:
Asthma. Allergic
rhinitis.
Single-nucleotide
polymorphism.
SNPstream. Toll-like
receptors.
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