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Consensus Statement on the Diagnosis,
Management, and Treatment of Angioedema Mediated by
Bradykinin. Part I. Classification, Epidemiology,
Pathophysiology, Genetics, Clinical Symptoms, and
Diagnosis |
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Spanish Study Group on Bradykinin-Induced
Angioedema (SGBA) (Grupo Español
de Estudio del Angioedema mediado por Bradicinina: GEAB)
T Caballero,1* ML Baeza,2,3# R Cabañas,1# A Campos,4# S
Cimbollek,5#
C Gómez-Traseira,1# T González Quevedo,5# M Guilarte,6#
J Jurado-Palomo,7# JI Larco,1# MC López-Serrano,1# M López-Trascasa,1,8 C
Marcos,9# JM Muñoz-
Caro,1 M Pedrosa,1# N Prior,1# M Rubio,2# A Sala-Cunill
6# |
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*Coordinator of the SGBA/GEAB
#Members of the SGBA/GEAB in alphabetical order
1Servicio de Alergia, Hospital La Paz Health Research
Institute (IdiPaz), Madrid, Spain
2Gregorio Marañón General University Hospital, Madrid,
Spain
3Centro de Investigación Biomédica en Red de
Enfermedades Raras (CIBERER)-U761
4La Fe University Hospital, Valencia, Spain
5Virgen del Rocío University Hospital, Sevilla, Spain
6Vall dHebron University Hospital, Barcelona, Spain
7Nuestra Señora del Prado General Hospital, Talavera de
la Reina, Toledo, Spain
8Centro de Investigación Biomédica en Red de
Enfermedades Raras (CIBERER)-U754
9Vigo University Hospital Complex, Vigo, Spain |
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Abstract |
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Background:
There are no Spanish
guidelines or
consensus statement
on bradykinin-induced
angioedema.
Aim: To
review the
pathophysiology,
genetics, and
clinical symptoms of
the different types
of bradykinin-induced
angioedema and to
draft a consensus
statement in light
of currently
available scientific
evidence and the
experience of
experts. This
statement will serve
as a guideline to
health
professionals.
Methods: The
consensus was led by
the Spanish Study
Group on Bradykinin-Induced
Angioedema (SGBA), a
working group of the
Spanish Society of
Allergology and
Clinical Immunology.
A review was
conducted of
scientific papers on
different types of
bradykinin-inducedangioedema
(hereditary and
acquired angioedema
due to C1 inhibitor
defi ciency,
hereditary
angioedema related
to estrogens,
angioedema induced
by angiotensin-converting
enzyme inhibitors).
Several discussion
meetings of the SGBA
were held in Madrid
to reach the
consensus.
Results: The
pathophysiology,
genetics, and
clinical symptoms of
the different types
of angioedema are
reviewed. Diagnostic
approaches are
discussed and the
consensus reached is
described.
Conclusions:
A review of
bradykinin-induced
angioedema and a
consensus on
diagnosis are
presented.
Key words:
Angioedema.
C1-inhibitor.
Bradykinin.
Estrogens. ACE
inhibitors
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