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Consensus Statement on the Diagnosis,
Management, and Treatment of Angioedema Mediated by
Bradykinin. Part II. Treatment, Follow-up, and Special
Situations |
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Spanish Study Group on Bradykinin-Induced
Angioedema (SGBA) (Grupo Español
de Estudio del Angioedema mediado por Bradicinina: GEAB)
T Caballero,1* ML Baeza,2,3# R Cabañas,1# A Campos,4# S
Cimbollek,5#
C Gómez-Traseira,1# T González Quevedo,5# M Guilarte,6#
J Jurado-Palomo,7# JI Larco,1# MC López-Serrano,1# M López-Trascasa,1,8 C
Marcos,9# JM Muñoz-
Caro,1 M Pedrosa,1# N Prior,1# M Rubio,2# A Sala-Cunill
6# |
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*Coordinator of the SGBA/GEAB
#Members of the SGBA/GEAB in alphabetical order
1Servicio de Alergia, Hospital La Paz Health Research
Institute (IdiPaz), Madrid, Spain
2Gregorio Marañón General University Hospital, Madrid,
Spain
3Centro de Investigación Biomédica en Red de
Enfermedades Raras (CIBERER)-U761
4La Fe University Hospital, Valencia, Spain
5Virgen del Rocío University Hospital, Sevilla, Spain
6Vall dHebron University Hospital, Barcelona, Spain
7Nuestra Señora del Prado General Hospital, Talavera de
la Reina, Toledo, Spain
8Centro de Investigación Biomédica en Red de
Enfermedades Raras (CIBERER)-U754
9Vigo University Hospital Complex, Vigo, Spain |
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Abstract |
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Background:
There are no
previous Spanish
guidelines or
consensus statements
on
bradykinin-induced
angioedema.
Aim: To draft
a consensus
statement on the
management and
treatment of
angioedema mediated
by bradykinin in
light of currently
available scientific
evidence and the
experience of
experts. This
statement will serve
as a guideline to
health
professionals.
Methods: The
consensus was led by
the Spanish Study
Group on
Bradykinin-Induced
Angioedema, a
working group of the
Spanish Society of
Allergology and
Clinical Immunology.
A review was
conducted of
scientific papers on
different types of
bradykinin-induced
angioedema
(hereditary and
acquired angioedema
due to C1 inhibitor
defi ciency,
hereditary
angioedema related
to estrogens,
angioedema induced
by
angiotensin-converting
enzyme inhibitors).
Several discussion
meetings were held
to reach the
consensus.
Results:
Treatment approaches
are discussed, and
the consensus
reached is
described. Specifi c
situations are
addressed, namely,
pregnancy,
contraception,
travelling, blood
donation, and organ
transplantation.
Conclusions:
A review of and
consensus on
treatment of
bradykinin-induced
angioedema is
presented.
Key words:
Angioedema.
C1-inhibitor.
Bradykinin.
Estrogens. ACE
inhibitors.
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