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GEMA 2009
 

Effect of Bilastine Upon Nasal Obstruction
 
I Dávila1, J Sastre2, J Mullol3, J Montoro4, I Jáuregui5, M Ferrer6, A del Cuvillo7, J Bartra8, A Valero8
1Department of Immunoallergy, Salamanca University Healthcare Complex, Salamanca, Spain
2Department of Allergy, Jiménez Díaz Foundation, Madrid, Spain. Biomedical Research Centre Network for Respiratory Diseases (CIBERES)
3Rhinology Unit & Smell Clinic, ENT Department. Clinical and Experimental Respiratory Immunoallergy (IDIBAPS). Clinic Hospital. Barcelona, Spain. Biomedical Research Centre Network for Respiratory Diseases (CIBERES)
4Allergy Section, Elda General Hospital, Alicante, Spain
5Department of Allergy, Basurto Hospital. Bilbao, Spain
6Department of Allergy. Clínica Universidad de Navarra. Medical School. Pamplona, Spain
7Astarté ENT Centre. Cádiz, Spain
8Allergy Unit. Department of Pneumology and Respiratory Allergy. Clinic Institute of Thorax (ICT). Clinical and Experimental Respiratory Immunoallergy (IDIBAPS). Clinic Hospital. Barcelona, Spain. Biomedical Research Centre of Respiratory Diseases (CIBERES)

J Investig Allergol Clin Immunol 2011; Vol. 21, Suppl. 3: 2-8
 

 Abstract


H1 antihistamines constitute one of the main references for the treatment of allergic rhinitis. Classically, these drugs have been considered effective in controlling sneezing, rhinorrhea and itching, though they have not been regarded as particularly effective in application to nasal obstruction. The most recent studies, involving second-generation H1 antihistamines (desloratadine, fexofenadine, levocetirizine, rupatadine), have shown these drugs to offer effects upon nasal obstruction significantly superior to those of placebo. The present review examines the effect of bilastine, a new, potent and highly specifi c H1 antihistamine without sedative effects or cardiac toxicity, upon nasal
obstruction. The analysis of the data from the different clinical trials indicates that in patients with allergic rhinitis, the effect of bilastine upon nasal obstruction is superior to that of placebo and similar to that of other second-generation H1 antihistamines, manifesting within 24 hours after the start of treatment.

Key words: Bilastine. Nasal obstruction. Antihistamines. Allergic rhinitis.