|
F Qian,1* Q Zhang,2*
L Zhou,3 G Ma,1 G Jin,4
Q Huang,5 K Yin3 |
|
1Department of Respiratory
Medicine, Affi liated Hospital, Jiangsu University,
Zhenjiang, Jiangsu, China
2Department of Respiratory Medicine, Affi
liated Changzhou No.2 Peoples Hospital, Nanjing Medical
University, Changzhou, China
3Department of Respiratory Medicine, First
Affi liated Hospital, Nanjing Medical University,
Nanjing, China
4Department of Epidemiology and
Biostatistics, Cancer Research Center, Nanjing Medical
University, Nanjing, China
5Department of Otolaryngology, Affi liated
Hospital, Jiangsu University, Zhenjiang, Jiangsu, China
6These authors contributed equally to the
article. |
|
Abstract |
|
Background and
Objectives:
Interleukin (IL) 17F
is a marker of type
17 helper T cells
and has a
proinflammatory role
in asthma. The aim
of the present study
was to assess the
possible association
between asthma and
polymorphisms in the
IL17F gene in
a Chinese
population.
Methods: A
total of 318
asthmatic patients
and 352 nonasthmatic
controls were
recruited. Two
single-nucleotide
polymorphisms in
IL17F (rs763780 and
rs13209590) were
detected using
GenomeLab SNPstream.
Logistic regression
methods were used to
analyze data.
Results: A
significantly lower
frequency of the C
allele in rs763780
was observed in the
control group (P=.0148).
The rs763780 TC
heterozygote was
associated with an
increased risk of
asthma, and a
similar trend was
observed assuming a
codominant genotype
effect (adjusted OR,
1.58; 95% CI,
1.06-2.36; P=.0148;
adjusted OR, 1.64;
95% CI, 1.10-2.45;
P=.0217).
Furthermore, a novel
finding of the
present study was
that this
association was
exclusive to males
(adjusted OR, 1.79;
95% CI, 1.06-3.05;
P=.0308) and
patients with higher
immunoglobulin E
levels (≥ 1.85 IU/mL)
(adjusted OR, 1.88;
95% CI, 1.10-3.22;
P=.0213). We
also found that the
haplotype with minor
alleles for rs763780
was associated with
an increased risk of
asthma (adjusted OR,
1.62; 95% CI,
1.11-2.35; P=.0115).
Conclusions:
Our findings
indicated that
polymorphisms might
play a role in
susceptibility to
asthma.
Key words:
Asthma. IgE.
Interleukin 17F.
Single-nucleotide
polymorphism.
|
|
|
|
| |
|
|
