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Key Issues in Hymenoptera Venom Allergy: An Update

Alfaya Arias T1, Soriano Gómis V2, Soto Mera T3, Vega Castro A4, Vega Gutiérrez JM5, Alonso Llamazares A4, Antolín Amérigo D6, Carballada Gonzalez FJ7, Dominguez Noche C8, Gutierrez Fernandez D9, Marques Amat L10, Martinez Arcediano A11, Martinez San Ireneo M12, Moreno Ancillo A13, Puente Crespo Y14, Ruiz Leon B15, Sánchez Morillas L16 (Hymenoptera Allergy Committee of the SEAIC)

1Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
2Hospital General Universitario de Alicante, Alicante, Spain
3Complejo Hospitalario de Pontevedra, Pontevedra, Spain
4Hospital Universitario, Gerencia de Atención Integrada de Guadalajara, Guadalajara, Spain
5Hospital Universitario Río Hortega, Valladolid, Spain
6Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain
7Hospital Universitario Lucus Augusti (HULA), Lugo, Spain
8Hospital Virgen del Puerto, Plasencia, Spain
9Hospital Universitario Puerta del Mar, Cádiz, Spain
10Hospitales Universitarios Santa María y Arnau de Vilanova, Lleida, Spain
11Hospital Universitario Araba (HUA), Vitoria-Gasteiz, Spain
12Hospital Virgen del Valle, Toledo, Spain
13Hospital Nuestra Señora del Prado, Talavera de la Reina, Spain
14Hospital Universitario Virgen Macarena, Sevilla, Spain
15Hospital Universitario Reina Sofía, Córdoba, Spain
16Hospital Universitario Clínico San Carlos, Madrid, Spain

J Investig Allergol Clin Immunol 2017; Vol 27(1) : 19-31
doi: 10.18176/jiaci.0123

In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed.
The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described.
Finally, we analyze the issue of mast cell activation syndrome closely related to hymenoptera allergy, which has become a new diagnostic challenge for allergists given its high prevalence in patients with venom anaphylaxis.

Key words: Hymenoptera, Molecular diagnosis, Venom immunotherapy, Polistes dominula, Mastocytosis