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Oral Immunotherapy With Egg and Milk: Changes in Peripheral Serum Cytokines Are Not Predictive Factors for Severe Adverse Reactions or for the Final Report

García-Lirio E1, Gonzalez Diaz C2, Gonzalez Hermosa A2, Gamboa P1, Aranguren R3, Sanz ML3

1Servicio de Alergología, Hospital Universitario Cruces, Barakaldo, Spain
2Servicio de Pediatría, Hospital Universitario de Basurto, Bilbao, Spain
3Departamento de Alergología, Clínica Universidad de Navarra, Pamplona, Spain

J Investig Allergol Clin Immunol 2018; Vol 28(1) : 24-28
doi: 10.18176/jiaci.0212

Introduction: Oral immunotherapy (OIT) is a new approach in patients with food allergy. Various immunological mechanisms underlie the reversal of food allergy. In this paper, we study possible changes in peripheral cytokine patterns during OIT.
Methods: Determinations of cytokines in peripheral blood were made in children who had milk or egg allergy and who received OIT. The determinations were made before and after OIT, and again following a final repeat oral challenge a month after a diet excluding the culprit food.
Results: No significant changes were registered in the cytokines studied (IL-2, IL-4, IL-6, IL-10, IL-12, IL-17, IFNγ, and TNF) at any of the 3 time points. Similarly, no differences in cytokine pattern were observed between children who had presented anaphylaxis during OIT and those who overcame or did not overcome the final oral challenge.
Discussion: Peripheral cytokines do not undergo significant changes during the OIT process. They are not predictors of serious adverse reactions or the final result of the OIT.

Key words: Egg allergy, Milk allergy, Oral immunotherapy, Cytokines