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Analysis of Lymphocyte and Clinical Profile among Non-monogenic Common Variable Immunodeficiency Patients with and without Class Switch Recombination Defect

Zavareh FT1,2,3,4, Mirshafiey A1,4,5, Yazdani R1,3,6, Keshtkar AA7, Abolhassani H1,8,9, Kiaee F10, Parvaneh N11, Shariat M11, Rezaei N1,3,12, Aghamohammadi A1

1Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
2Central Research Laboratory, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
3Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
4Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
5Livonian Biotech Millennium Ltd, Riga, LV-1013, Latvia.
6Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
7Department of Health Sciences Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
8Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
9Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.
10Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
11Department of Pediatrics, Division of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
12Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

J Investig Allergol Clin Immunol 2023; Vol. 33(6)
doi: 10.18176/jiaci.0900

Key words: Common Variable Immunodeficiency (CVID), Unsolved patients, Class switch recombination, Lymphocyte subsets, Clinical phenotype