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Deep intronic 9q21.11 polymorphism contributes to atopic dermatitis risk through methylation regulated expression of tight junction protein 2

Eliza Lim YY1, Yie Sio Y1, Say YH1,2,3†, Reginald K3, Tim Chew F1

1Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
2Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR) Kampar Campus, Kampar, Perak, Malaysia
3Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Malaysia

J Investig Allergol Clin Immunol 2025; Vol. 35(3)
doi: 10.18176/jiaci.0978

Key words: Atopic dermatitis, Genome-wide association studies, Epigenetics, Methylation, Expression quantitative trait loci, Tight junction protein, Transepidermal water loss, Epidermal hyperplasia