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Rapid drug desensitization protocol in delayed hypersensitivity reactions to CFTR modulator drugs: When everyday counts

Rodríguez-Otero N1, Fernández-Lozano C2, Vicente-Santamaría S3, Díaz-Montalvo L1, Pérez Menéndez-Conde C4, Sola-Martínez FJ1

1Allergy Department, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain
2Biochemistry-Research Department, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain
3Paediatric Gastroenterology, Hepatology and Nutrition and Cystic Fibrosis Section, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain
4Pharmacy Department, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain 

J Investig Allergol Clin Immunol 2024; Vol. 34(5)
doi: 10.18176/jiaci.0982

Key words: CFTR modulators, Cystic fibrosis, Delayed hypersensitivity reactions, Rapid drug desensitization, Lymphocyte transformation test