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Original Article


Chronic autoreactive urticaria at six years of age


R. Asero, M. Lorini*, A. Tedeschi*

Allergy Unit, Clinica San Carlo, Paderno Dugnano (Milano), and *First Division of Internal Medicine, IRCCS
Ospedale Maggiore Policlinico, Milano, Italy

J Invest Allergol Clin Immunol 2004; Vol. 14(4): 343-345



A case of chronic urticaria in a child 6 years old is described. The strong skin reactivity upon intradermal injection of autologous serum suggested an autoreactive pathogenesis; however, patient’s serum was unable to induce histamine release from basophils in-vitro, indicating the presence of a histamine-releasing factor specific
for mast cells, and possibly other than an anti-FcεRI or anti-IgE antibody. Intradermal test with autologous serum may be useful in revealing the autoreactive nature of chronic urticaria and can avoid a frustrating search for other causes of the disease. In children presenting with chronic or recurrent urticaria the diagnostic workup should
include the autologous serum skin test.

Key words: autologous serum skin test, childhood, chronic urticaria.