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Original Article


Bone mineral density in asthmatic patients using low dose inhaled glucocorticosteroids


O. El1, S. Gulbahar2, E. Ceylan3, G. Ergor4, E. Sahin5, O. Senocak6, S. Oncel7, A. Cımrın8,

1,2,5,6,7: Department of Physical Medicine and Rehabilitation. Dokuz Eylul Universtiy
School of Medicine. Balcova. 35340 Izmir. Turkey
3,8: Department of Respiratory Medicine. Dokuz Eylul Universtiy
School of Medicine. Balcova. 35340 Izmir. Turkey
4: Department of Public Health. Dokuz Eylul Universtiy
School of Medicine. Balcova. 35340 Izmir. Turkey

J Invest Allergol Clin Immunol 2005; Vol. 15(1): 57-62



Inhaled glucocorticosteroids are clearly beneficial in subjects with moderate or severe asthma since they are well tolerated, reduce symptoms, and improve quality of life. Some studies suggest that inhaled glucocorticosteroids can adversely affect bone mineral density. The aim of this study is to determine the effects of inhaled glucocorticosteroid therapy on bone mineral density in female patients. Forty-five asthmatic female patients
(36 premenopousal and 9 postmenopausal) and forty-six healthy control subjects were included in the study. Bone mineral density was measured from lumbar spine (L1-4) and femur (neck, trochanter, and Ward’s triangle) by dual energy X-Ray absorptiometry. Age, occupation, menopause and smoking status, alcohol consumption, body mass
index, previous fractures, family history of fractures, menstrual history, ooferectomy, number of pregnancies, the duration of lactation, physical activity and calcium intake were questioned according to the European Vertebral Osteoporosis Study Group (EVOS) form. Cumulative inhaled glucocorticosteroid dose was calculated. T score of femoral neck and T score and bone mineral density of Ward’s triangle were significantly lower in asthmatic patients compared to control group but no statistically significant correlation was found between the disease duration, inhaled steroid treatment duration, cumulative inhaled dose and annual inhaled steroid dose and bone mineral density measurement. These results suggest that in asthmatic patients using low dose inhaled corticosteroids
bone mineral density is lower than in healthy controls but it is still unclear if asthma by itself is a risk factor for osteoporosis.

Key words
: Inhaled steroid, asthma, bone mineral density, osteoporosis