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Original Article


Acute effect of nebulized budesonide in asthmatic children


Y. Nuhoglu1, E. Atas2, C. Nuhoglu3, M. Iscan2, S. Ozcay2

SSK Goztepe Training and Research Hospital, 1Department of Allergy and 2Department of Pediatrics, Istanbul, Turkiye Haydarpasa Numune Training and Research Hospital
3Department of Pediatrics, Istanbul, Turkiye

J Invest Allergol Clin Immunol 2005; Vol. 15(3): 197-200



The acute anti-inflammatory effects of inhaled steroids at high doses and their use at home and as emergency treatment of acute asthma attacks in children have been evaluated in many clinical studies. However very little is known about their additional bronchodilator response to systemic steroids plus nebulized salbutamol in the early management in children. Asthmatic patients aged between 5-15 years were investigated in a double-blind, placebo-controlled fashion. Both the study group (Group I) and the control group (Group II) received three consecutive doses of nebulized salbutamol
 0.15 mg/kg/dose) and one dose of parenteral methylprednisolone (1 mg/kg/dose, intramuscularly). After this treatment, nebulized budesonide (1 mg/dose) was administered to patients in the study group and placebo (nebulized saline) was administered to patients in the control group. Pulmonary index scoring and peak flow meter was performed to both groups before and after the treatment.
There were twelve patients in Group I (mean age: 7.90 ± 2.34 years) and fourteen patients in Group II (mean age: 9.36 ± 2.55 years). There was no difference between the two groups with respect to age (p=0.1421), gender (p=1.000) and inhaled steroid prophylaxis rate (p=0.2177). No statistically significant difference was detected between the two groups with respect to the pulmonary index score (p=0.3528). Yet, there was a statistically significant difference between the two groups with respect to the increase in PEFR (p=0.0155).
The positive acute effect of nebulized budesonide in addition to systemic steroids and nebulized salbutamol in improving the spirometric indices in asthmatic children is an encouraging finding for further investigations of its routine use in the pediatric emergency department.

Key words:
Budesonide, nebulized, asthma, acute, children.