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Original Article


Effect of Extensively Hydrolyzed Milk Formula on Growth and Resistance to Bronchitis and Atopic Dermatitis in Infants and Toddlers


E Estrada-Reyes, 1 G García-Hernández ,2 A Martínez-Gimeno, 2 AA Nava-Ocampo 3

1 Consulta de Alergología Pediátrica, Hospital Angeles Metropolitano, Mexico City, Mexico
2 Sección de Neumología y Alergia, Hospital Universitario Materno-Infantil “12 de Octubre,” Madrid, Spain;
3 Division of Clinical Pharmacology & Toxicology, The Hospital for Sick Children, Toronto ON, Canada

J Investig Allergol Clin Immunol 2006; Vol. 16(3): 183-187



Objective: This study aimed to evaluate the adverse effects of extensively hydrolyzed milk formula on growth in infants and toddlers.

Methods: Prospectively, 45 infants and toddlers with a positive history of cow’s milk allergy confirmed by positive skin prick test and high IgE levels for either α-lactalbumin, ß-lactoglobulin, or casein and positive single-blind food challenge received extensively hydrolyzed milk formulas for 1 year. Sex-normalized percentiles of heights and weights of infants and toddlers before their enrollment in the study were compared to those at the end of the study. The contribution of breastfeeding, early use of bottle feeding and intake of adapted or special milk formulas, and history of bronchitis and atopic dermatitis on toddlers’ growth were also evaluated by multivariate analysis.

Results: Similar percentiles of the children’s weight and height were observed at the beginning of the study and 1 year later. According to the multivariate analysis, sex, breastfeeding, early bottle feeding, ingestion of adapted or special milk formulas, atopic dermatitis, and bronchitis were not correlated with either the children’s weight or
height at diagnosis of the allergy or at 1 year of follow-up (P > .10). Weights and heights were not different between toddlers who had atopic dermatitis or bronchitis during the study period and those who did not.

Conclusions: Growth of infants and toddlers with cow’s milk allergy was not affected by the intake of extensively hydrolyzed milk for 1 year. Atopic dermatitis and bronchitis did not appear to have any deleterious effect on these children’s growth.

Key words: Body measures. Food hypersensitivity. Postnatal growth.