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Case Report


Ibuprofen-Induced Fever in Sjögren’s Syndrome


MA Gonzalo-Garijo, P Bobadilla

Allergology Department. Infanta Cristina University Hospital. Badajoz, Spain

J Investig Allergol Clin Immunol 2006; Vol. 16(4): 266-267



A 68-year-old-woman with a medical history significant for Sjögren syndrome and leukocytoclastic vasculitis of small vessels presented to the emergency department with chills, malaise, a temperature of 39ºC, nausea, vomiting, and hypotension. Fifteen minutes earlier she had taken ibuprofen for flu-like symptoms. She was treated with a perfusion of intravenous saline, paracetamol, and ciprofloxacin with improvement 24 hours later. Three months later, she had a similar episode, without hypotension. An oral challenge test with ibuprofen in the hospital produced the same symptoms 3 hours after the last dose. She was treated with metamizole and paracetamol and was asymptomatic the next day. This is the first report of a febrile reaction to ibuprofen in a patient with Sjogren’s syndrome.

Key words: Adverse effects. Aseptic meningitis. Fever. Ibuprofen. Sjögren Syndrome.