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Case Report


Severe Dapsone Hypersensitivity Syndrome


O Sener,1 L Doganci,2 M Safali,3 B Besirbellioglu,4 F Bulucu,5 A Pahsa4

1 Division of Allergy,
2 Department of Microbiology and Clinical Microbiology,
3 Department of Pathology,
4 Department of Infectious Diseases
5 Department of Internal Medicine
Gulhane Military Medical Academy, Ankara, Turkey

J Investig Allergol Clin Immunol 2006; Vol. 16(4): 268-270



Dapsone, a potent antiparasitic and anti-inflammatory compound, is mainly used in the treatment of leprosy and a variety of blistering skin diseases. It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome. We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome. The clinical presentation mimicked a viral exanthema.

Key words: Dapsone hypersensitivity. Dermatitis herpetiformis.