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Case Report


Unilateral Conjunctival Chemosis as a Unique Symptom of Nonsteroidal Anti-Inflammatory Drug Intolerance


V Fuentes,1 C de Frutos,2 M de Barrio,3 R Barranco,1 T Herrero,3 P Tornero3

1 Private Practice, Madrid, Spain
2 Allergy Service, Hospital Universitario de la Princesa, Madrid, Spain
3 Allergy Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain

J Investig Allergol Clin Immunol 2007; Vol. 17(1): 62-64



Patients with nonsteroidal anti-inflammatory drug (NSAID) intolerance usually have cutanous-mucosal or/and respiratory symptoms.
We report the case of a patient who developed several episodes of left-eye conjunctivitis, manifested as conjunctival chemosis, with no other symptoms, after taking metamizole and other unidentified NSAIDs. We performed both a single blind placebo-controlled oral
challenge test and conjunctival challenge test with different NSAIDs. The single blind placebo-controlled oral challenge was positive to ketoprofen and diclofenac. The conjunctival challenge with diclofenac and fl urbiprofen was negative. The patient tolerated celecoxib and nabumetone.
We believe this to be an exceptional case of NSAID intolerance as conjunctival chemosis has not hitherto been included in any of the classic types of pseudoallergic reactions.

Key words: NSAID intolerance. Conjunctival chemosis.