Return to Contents in this Issue

Case Report


Systemic Dermatitis due to Tetrazepam


L Sánchez-Morillas,1 JJ Laguna-Martínez,1 M Reaño-Martos,2 E Rojo-Andrés,1 P Gómez-Tembleque Úbeda1

1 Allergology Department, Hospital Central de la Cruz Roja, Madrid, Spain
2 Allergology Department, Hospital Puerta de Hierro, Madrid, Spain

J Investig Allergol Clin Immunol 2008; Vol. 18(5): 404-406



Cutaneous adverse reactions to benzodiazepines seem to be rare.
We report a 61-year-old man with adverse reactions after ingestion of metamizole, diclofenac, and tetrazepam. Skin prick tests with metamizole, diclofenac, and tetrazepam were negative. Patch tests with metamizole, diclofenac, and tetrazepam (all at 5% in aqueous solution) were performed, and were positive for tetrazepam. Oral challenge was performed with metamizole, acetylsalicylic acid, diclofenac, and tetrazepam with a positive result for diclofenac and tetrazepam. The patient tolerated other benzodiazepines.
We present a patient who can tolerate diazepam but who had a type IV hypersensitivity reaction to tetrazepam confirmed by patch testing and oral challenge. The patient also presented an immediate hypersensitivity reaction after taking diclofenac.

Key words: Benzodiazepines. Contact dermatitis. Patch test. Tetrazepam.