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Original Article


Reference Values For Facilitating the Interpretation of the ESPRINT-15 Questionnaire (Spanish Version)


A Valero,1,2 E Baró,3 J Sastre,4 AM Navarro-Pulido,5 I Izquierdo,6 E Martí-Guadaño,7 M Ferrer,8,9 I Dávila,10 A del Cuvillo,11 C Colas,12 I Antepara,13 J Alonso,8,9 J Mullol2,14

1 Allergy Unit, Pneumology and Allergy Department, Hospital Clínic, Barcelona, Spain (Study Coordinator)
2 CIBER in Respiratory Diseases (CIBERES), Spain
3 3D Health Research, Barcelona, Epidemiology Department, Spain
4 Allergology Department, Jiménez Díaz Foundation, Madrid, Spain
5 Allergology Unit, El Tomillar Hospital, Dos Hermanas, Sevilla, Spain
6 J Uriach & Co, Barcelona, Spain
7 Hospital San Pere Claver Foundation, Barcelona, Spain
8 Health Services Research Unit, (IMIM-Hospital del Mar), Barcelona, Spain
9 CIBER in Epidemiology and Public Health (CIBERESP), Spain
10 Allergology Department, Hospital Clínico, Salamanca, Spain
11 Allergology Department, Dr Lobatón Clinic, Cadiz, Spain
12 Allergology Department, Hospital Clínico Universitario “Lozano Blesa,” Zaragoza, Spain
13 Allergology Department, Basurto Hospital, Bilbao, Spain
14 Rhinology Unit, Otorhinolaryngology Service, Hospital Clínic, Barcelona, Spain

J Investig Allergol Clin Immunol 2009; Vol. 19(5): 396-403



Objective: ESPRINT-15 is a specific, short-form instrument to measure health-related quality of life in adults suffering from allergic rhinitis.
The aim of this study was to obtain reference values in order to improve its interpretability.

Methods: ESPRINT-15 was administered to a representative sample of Spanish adults with allergic rhinitis. Means and percentiles were obtained, taking into account the kind of rhinitis (persistent/intermittent) and symptom severity (very mild/mild/moderate/severe).

Results: A total of 2756 patients participated in the study. Mean (SD) scores were significantly lower (better) for men than for women (2.2 [1.4] vs 2.4 [1.4], P<.001, effect size [ES]0.15). Patients with intermittent rhinitisshowed better scores than patients with persistent rhinitis (2.1 [1.4] vs. 2.5 [1.4], P<.001, ES0.21). Mean (SD) scores were higher (worse) when severity of symptoms increased, ranging from 0.9 (0.9) (very mild) to 3.7 (1.0) (severe) (ES1.0 between each consecutive group of symptom severity).

Conclusions: The magnitude of the differences found among groups of patients reinforces the usefulness of providing reference values stratified by gender, type of allergic rhinitis, and symptom severity. The percentiles obtained can be used in clinical practice to evaluate individual scores, and assign the patient to the corresponding reference group.

Key words: Allergic rhinitis. Adults. Specific questionnaire. Health perception. Reference values. Spanish version.