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Case Report


Study of Cross-Reactivity Between Proton Pump Inhibitors


MT Sobrevia Elfau, M Garcés Sotillos, L Ferrer Clavería, N Segura Arazuri, S Monzón Ballarín, C Colás Sanz

Hospital Clínico Universitario “Lozano Blesa”, Zaragoza, Spain

J Investig Allergol Clin Immunol 2010; Vol. 20(2): 157-161



Several studies have demonstrated different cross-reactivity patterns between proton pump inhibitors (PPIs). The aim of this study was to investigate cross-reactivity between commercially available PPIs and establish a procedure for performing cutaneous tests for verifying PPI allergy.
We performed skin prick and intradermal tests with all commercially available PPIs in 5 patients with clinical allergy to omeprazole and observed positive results in all patients.
We report 5 cases of immunoglobulin (Ig) E–mediated allergy to omeprazole and document cross-reactivity by skin testing between all the PPIs studied. We also found that the probability of confi rming an IgE-mediated mechanism with skin tests decreases with time. Finally, we propose a hypothesis that could explain the different PPI cross-reactivity patterns reported.

Key words: Esomeprazole. Lansoprazole. Omeprazole. Pantoprazole. Proton pump inhibitors. Rabeprazole.