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Original Article


Polymorphisms in the Toll-like Receptor 2 Subfamily and Risk of Asthma: A Case-control Analysis in a Chinese Population


F-H Qian,1* Q Zhang,2* L-F Zhou,3 G-F Jin,4 J-L Bai,5 K-S Yin3

1Department of Respiratory Medicine, Affi liated Hospital, Jiangsu University, Zhenjiang, Jiangsu, China
2Department of Respiratory Medicine, Affi liated Changzhou No.2 people s hospital, Nanjing Medical University, Changzhou, China
3Department of Respiratory Medicine, First Affi liated Hospital, Nanjing Medical University, Nanjing, China
4Department of Epidemiology and Biostatistics, Cancer Research Center, Nanjing Medical University, Nanjing, China
5Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
*Both authors contributed equally to this article.

J Investig Allergol Clin Immunol 2010; Vol. 20(4): 340-346



Background and objective: Cell activation through toll-like receptors (TLRs) has robust bipolar effects on host immunity and the pathogenesis of asthma. The TLR2 subfamily is a pivotal member of the TLR family. We sought to determine whether mutations in TLR2 subfamily genes affect the risk of asthma.

Methods: A total of 318 asthmatic patients and 352 nonasthmatic controls were recruited. Eight single-nucleotide polymorphisms in TLR2 subfamily genes were detected using GenomeLab SNPstream (Beckman Coulter, Fullerton, California, USA).

Results: We found that patients with the TLR2/rs7656411 TT variant homozygote had a significantly reduced risk of asthma when compared with those with the GG wild-type homozygote (adjusted odds ratio [OR], 0.63; 95% confidence interval [CI], 0.41-0.98; P=.036). Furthermore, a positive association was observed between the T allele of rs2381289 in TLR6 and allergic rhinitis in asthma (OR, 1.79; 95% CI, 1.10-2.91; P=.025), while the A allele of rs11466651 in TLR10 was negatively associated with allergic rhinitis (OR, 0.49; 95% CI, 0.26-0.95; P=.046).

Conclusion: Our results indicate that a genetic variant in the TLR2 subfamily may play a role in susceptibility to asthma.

Key words: Asthma. Allergic rhinitis. Single-nucleotide polymorphism. SNPstream. Toll-like receptors.