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P Barranco,1 C
Pérez-Francés,2 S Quirce,1 E
Gómez-Torrijos,3 R Cárdenas,3 S
Sánchez-García,4 F Rodríguez-Fernández,5
P Campo,6 JM Olaguibel,7 J Delgado8
Severe Asthma Working Group of the SEAIC Asthma
Committee |
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1Department of Allergy,
Hospital La Paz Institute for Health Research (IdiPAZ),
Madrid, Spain
2Department of Allergy, Hospital
Universitario Dr. Peset, Valencia, Spain
3Department of Allergy, Hospital General de
Ciudad Real, Ciudad Real, Spain
4Section of Allergy, Hospital Infantil
Universitario del Niño Jesús, Madrid, Spain
5Department of Allergy, Hospital
Universitario Marqués de Valdecilla, Santander, Spain
6Unidad de Gestión Clínica de Alergología,
Hospital Carlos Haya, Málaga, Spain
7Department of Allergy, Complejo Hospitalario
de Navarra, Pamplona, Spain
8Unidad de Gestión Clínica de Alergología,
Hospital Virgen Macarena, Sevilla, Spain |
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Abstract |
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Background:
The concepts of
asthma severity,
control, and
exacerbation are
important in the
evaluation of
patients and their
response to
treatment. However,
terminology is not
standardized, and
terms are often used
interchangeably.
Patients with
uncontrolled severe
asthma pose a major
health care problem.
Over the last
decade, it has
become increasingly
clear that, in order
to facilitate the
development of novel
targeted therapies,
patients must be
further
characterized and
classified.
Objective: To
draft a consensus
statement on the
diagnosis,
management, and
treatment of severe
uncontrolled asthma.
The statement is
meant to serve as a
guideline for health
professionals and
clinical
researchers.
Methods: The
consensus was led by
the Severe Asthma
Working Group of the
Spanish Society of
Allergology and
Clinical Immunology
Asthma Committee. A
review was conducted
of the best
available scientific
evidence (until
December 2011) on
severe asthma in
adults and children.
Results:
Definitions for
severe asthma, level
of control, and
exacerbation are
developed. Different
phenotypes and
endophenotypes of
severe uncontrolled
asthma and new
specific therapeutic
interventions are
presented. A
systematic algorithm
for the evaluation
of patients
presenting with
severe persistent
asthma symptoms is
proposed.
Conclusions:
A consensus
statement on the
diagnosis,
management, and
treatment of severe
uncontrolled asthma
is presented.
Key words:
Asthma. Severity.
Control.
Exacerbations.
Algorithm.
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