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M Gharagozlou,1 E
Farhadi,2,4 M Khaledi,5 N
Behniafard,1 S Sotoudeh,1 R
Salari,2 B Darabi,1 SM Fathi,1
M Mahmoudi,6 A Aghamohammadi,1,7
AA Amirzargar,2,3 N Rezaei1,2,3,7 |
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1 Pediatrics Center of
Excellence, Children's Medical Center, Tehran University
of Medical Sciences, Tehran, Iran
2 Molecular Immunology Research Center,
School of Medicine, Tehran University of Medical
Sciences, Tehran, Iran
3 Department of Immunology, School of
Medicine, Tehran University of Medical Sciences, Tehran,
Iran
4 Hematology Department, School of Allied
Medical Science, Tehran University of Medical Sciences,
Tehran, Iran
5 Growth and Development Research Center,
Tehran University of Medical Sciences, Tehran, Iran
6 Rheumatology Research Center, Tehran
University of Medical Sciences, Tehran, Iran
7 Research Center for Immunodefi ciencies,
Tehran University of Medical Sciences, Tehran, Iran |
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Abstract |
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Background:
Atopic dermatitis
(AD) is a chronic
skin disorder of
unknown origin that
usually manifests
for the first time
in early infancy.
Different types of
genetic
predisposition and
environmental
factors seem to be
associated with the
disease.
Methods: This
study was performed
to evaluate the
frequency of
alleles, genotypes,
and haplotypes of
interleukin (IL) 6
single-nucleotide
polymorphisms (SNPs)
at positions 174
and nt565 in 89
Iranian children
with AD and 139
healthy controls.
Results: The G
allele was
significantly more
frequent at position
174 in IL6 in
atopic patients than
in the healthy
controls (P<.001;
OR, 2.82). Genotype
GG was found at the
same position in 71%
of the patients;
this frequency was
significantly higher
than the frequency
of 30% recorded in
the controls
(P<.001; OR, 5.60).
The GG haplotype of
IL6 (174, nt565)
was significantly
more frequent in the
atopic patients than
in the healthy
controls (P<.001;
OR, 2.99).
Conclusions: A
significant increase
in the frequency of
the G allele and GG
genotype at position
174 of IL6 was
found in patients
with AD, thus
suggesting that
production of this
cytokine is greater
in atopic patients.
Key words:
Atopic dermatitis.
Cytokine. Single
gene polymorphisms.
Interleukin 6. |
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