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Original Article


Association between Genetic Polymorphisms of ß2 Adrenergic Receptors and Nocturnal Asthma in Egyptian children


RA Karam,1 NA Sabbah,1 HE Zidan,1 HMA Rahman2

1Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Paediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

J Investig Allergol Clin Immunol 2013; Vol. 23(4): 262-266



Background: Identification of the genetic basis of asthma may contribute to the discovery of effective asthma drugs.

Objective: Our aim was to estimate the association between B2 adrenergic receptor (ADRB2) polymorphisms and nocturnal asthma in Egyptian children.

Methods: ADRB2 polymorphisms Gly16 and Glu27 were genotyped in 200 Egyptian children (90 with nocturnal asthma and 110 healthy controls) using allele-specific polymerase chain reaction.

Results: The homozygous (Gly16) genotype significantly increased the risk of nocturnal asthma (odds ratio [OR], 3.2; 95% CI, 1.3-7.7; P=.003), as did the Gly allele (OR, 1.8: 95% CI, 1.2-2.8).

Conclusions: Our study demonstrated that nocturnal asthma was associated with ADRB2 Arg/Gly polymorphisms but not with ADRB2 Gln/Glu polymorphisms.

Key words: Nocturnal asthma. Egyptian children. B2 adrenergic receptor polymorphisms. Allergy. Polymorphism.