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Use of Second Generation H1 Antihistamines in Special Situations


I Dávila1, A del Cuvillo2, J Mullol3, I Jáuregui4, J Bartra5, M Ferrer6, J Montoro7, J Sastre8, A Valero5

1Immunoallergy Department, Salamanca University Welfare Complex, IBSAL, Salamanca, Spain
2Rhinitis and Asthma Unit, Jerez Hospital, Cadiz, Spain
3Rhinology and Olfactory Clinical Unit, Otorhinolaryngology Unit, Hospital Clínic, Barcelona, Spain
4Allergy Department, Basurto Hospital, Bilbao, Spain
5Pneumology and Respiratory Allergy Department, Hospital Clínic (ICT), Barcelona. Biomedical Research Centre in Respiratory Illnesses Network (CIBERES), IDIBAPS, Spain
6Allergology Department, Navarra University Clinic, Pamplona, Spain
7Allergy Unit, Arnau de Vilanova University Hospital, Faculty of Medicine, Catholic University of Valencia “San Vicente Mártir”, Valencia, Spain
8Allergy Department, Jiménez Díaz Foundation, Madrid, Spain

J Investig Allergol Clin Immunol 2013; Vol. 23, Suppl. 1: 1-16



Antihistamine drugs are one of the therapeutic classes most used at world level, at all ages and in multiple situations. Although in general they have a good safety profile, only the more recent drugs (second generation antihistamines) have been studied specifically with regard to the more important safety aspects. Given the variety of antihistamine drugs, they cannot all be considered equivalent in application to various special clinical situations, so that the documented clinical experience must be assessed in each case or, in the absence of such, the particular pharmacological characteristics of each molecule for the purpose of recommendation in these special situations.
In general, there are few clinical studies published for groups of patients with kidney or liver failure, with concomitant multiple pathologies (such as cardiac pathology), in extremes of age (paediatrics or geriatrics) and in natural stages such as pregnancy or lactation, but these are normal situations and it is more and more frequent (among the elderly) for antihistamine drugs to be recommended. This review sets out the more relevant details compiled on the use of antihistamines in these special situations.

Key words
: Antihistamines H1. Liver failure. Kidney failure. Children. The elderly. Pregnancy. Pregnant women. Lactation.