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Original Article


Association Between CC Motif Chemokine Ligand 5 (CCL5) Polymorphisms and Asthma Risk: An Updated Meta-analysis


Huang H*, Nie W*, Zang Y*, Chen J*, Xiu Q

Department of Respiratory Medicine, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
*These authors contributed equally to this study

J Investig Allergol Clin Immunol 2015; Vol. 25(1): 26-33



Background: Findings regarding the associations between the CC motif chemokine ligand 5 (CCL5) -403G/A and -28C/G polymorphisms and asthma risk are controversial. We performed a meta-analysis to determine whether CCL5 polymorphisms are associated with asthma risk.

Methods: We searched the Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies published before June 2013. The strength of associations was calculated using ORs with 95% CIs.

Results: Twenty case-control studies were included in this meta-analysis. We did not observe a significant association between the CCL5 -403G/A polymorphism and asthma risk (OR, 1.10; 95% CI, 0.93-1.30; P=.25). The CCL5 -28C/G polymorphism, however, was associated with a significantly elevated asthma risk (OR, 1.17; 95% CI, 1.02-1.33; P=.02). Subgroup analyses found that the CCL5 -28C/G polymorphism was significantly associated with asthma risk in Asians (OR, 1.16; 95% CI, 1.01-1.33; P=.04) and children (OR, 1.29; 95% CI, 1.03-1.63; P=.03).

Conclusions: This meta-analysis suggests that the CCL5 -28C/G polymorphism is a risk factor for asthma.

Key words: Asthma. CCL5. Meta-analysis. Polymorphism.