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Immune Polarization in Allergic Patients: Role of the Innate Immune System


Escribese MM1, Gómez-Casado C2, Barber D1, Diaz-Perales A2

1Institute for Applied Molecular Medicine (IMMA), School of Medicine, Universidad CEU San Pablo, Madrid, Spain
2Centre for Plant Biotechnology and Genomics, Campus de Montegancedo, Pozuelo de Alarcón, Madrid, Spain

J Investig Allergol Clin Immunol 2015; Vol. 25(4): 251-258



Allergens come into contact with the immune system as components of a very diverse mixture. The most common sources are pollen grains, food, and waste. These sources contain a variety of immunomodulatory components that play a key role in the induction of allergic sensitization. The way allergen molecules bind to the cells of the immune system can determine the immune response. In order to better understand how allergic sensitization is triggered, we review the molecular mechanisms involved in the development of allergy and the role of immunomodulators in allergen recognition by innate cells.

Key words: Innate immune system. Allergy. Allergens.