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T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi G1,2,3, Rezaei N2,4,5, Kiaee F2,3, Tavakolinia N2,3, Yazdani R6, Mirshafiey A7, Aghamohammadi A2,3

1Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
2Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
4Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
6Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
7Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

J Investig Allergol Clin Immunol 2016; Vol 26(4) : 233-243
doi: 10.18176/jiaci.0069

Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-celldifferentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients.

Key words: Common variable immunodeficiency, T cell, Helper T cells, Regulatory T cells.